NFAT*

Protein NFAT* map

Identifiers
nuclear factor of activated T-cells cytoplasmic calcineurin-dependent 1
HUGO:NFATC1 HGNC:7775 ENTREZ:4772 UNIPROT:O95644 GENECARDS:NFATC1 REACTOME:60119 KEGG:4772 ATLASONC:GC_NFATC1 WIKI:NFATC1
nuclear factor of activated T-cells cytoplasmic calcineurin-dependent 3
HUGO:NFATC3 HGNC:7777 ENTREZ:4775 UNIPROT:Q12968 GENECARDS:NFATC3 REACTOME:60123 KEGG:4775 ATLASONC:GC_NFATC3 WIKI:NFATC3
nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2
NF-ATP, NFAT1, NFATp
HUGO:NFATC2 HGNC:7776 ENTREZ:4773 UNIPROT:Q13469 GENECARDS:NFATC2 REACTOME:60121 KEGG:4773 ATLASONC:NFATC2ID44004ch20q13 WIKI:NFATC2
NF-ATC, NFAT2, NFATc
nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4
NFAT3
HUGO:NFATC4 HGNC:7778 ENTREZ:4776 UNIPROT:Q14934 GENECARDS:NFATC4 KEGG:4776 ATLASONC:GC_NFATC4 WIKI:NFATC4
UNIIPROT:Q149934
nuclear factor of activated T-cells 5, tonicity-responsive
NFAT5
HUGO:NFAT5 HGNC:7774 ENTREZ:10725 UNIPROT:O94916 GENECARDS:NFAT5 KEGG:10725 ATLASONC:GC_NFAT5 WIKI:NFAT5

Maps_Modules
 Survival  map  / MAPK  map
 Survival  map  / WNT_NON_CANONICAL  map

References
NFAT sites are often located close to AP-1 sites in many promoters allowing for cooperative binding and synergistic trans-activation of numerous genes. NFATc1 is crucial to the differentiation of Th cells to the Th2 effector phenotype.
PMID:11274345
NFAT1 has at least 21 phosphorylation sites, 18 are located within the regulatory domain, 14 are conserved in the NFAT family 13 are dephosphorylated upon stimulation which is required to cause full exposure of NLS, mask an NES, needed for full activation: 7 serine residues in SRR1 domain of which 5 are phosphorylated (S170, S173, S174, S176, S177, S179, and S182), S215, S219, S223, S238, S245, S270, S276, S278, S282, and S2328.
PMID:11030334
NFAT5 activity is not regulated by phosphorylation but osmotic stress
PMID:11402342

NFAT*|​pho@Cytoplasm

References
s_mpk1_re169( Survival  map ):
JNK could phosphorylate NFAT4 and NFAT2 inhibiting their nuclear translocation.
PMID:11274345

NFAT*@Nucleus

References
s_mpk1_re170( Survival  map ):
JNK could phosphorylate NFAT4 and NFAT2 inhibiting their nuclear translocation.
PMID:11274345
s_wnc3_re21:( Survival  map ) This arrow is to indicate that phosphorylated NFAT3 is also involved in complex formation of NFAT/AP-1
s_wnc3_re22:( Survival  map ) To indicate that sumoylated NFAT1 forms as well NFAT/AP comlexes.
s_wnc3_re24:( Survival  map ) This isoform of NFAT1 forms also NFAT/AP-1 complexes.
s_wnc2_re56( Survival  map ):
DYRK1A/B primes NFAT in the nucleus, DYRK2 in the cytosol
PMID:16511445
s_wnc2_re85( Survival  map ):
S272 and S89 are PKA sites in NFAT3
PMID:10611249
s_wnc3_re5:( Survival  map ) PMID:15657420
s_wnc3_re8:( Survival  map ) PMID:11796223
s_wnc3_re10:( Survival  map ) PMID:22275375, PMID:15657064, PMID:16396959, PMID:16998587

NFAT*@Cytoplasm

References
s_mpk1_re169( Survival  map ):
JNK could phosphorylate NFAT4 and NFAT2 inhibiting their nuclear translocation.
PMID:11274345

NFAT*|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho@Cytoplasm

References
s_wnc2_re59( Survival  map ):
PMID:10788511, PMID:10094050, PMID:9585406
For a more detailed mechanism see CRM1 in map Nucleus_MTOR

NFAT*|​pho|​pho@Nucleus

References
s_wnc2_re56( Survival  map ):
DYRK1A/B primes NFAT in the nucleus, DYRK2 in the cytosol
PMID:16511445
s_wnc2_re58:( Survival  map ) PMID:16511445, PMID:15121840

NFAT*|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho@Nucleus

References
s_wnc2_re58:( Survival  map ) PMID:16511445, PMID:15121840
s_wnc2_re59( Survival  map ):
PMID:10788511, PMID:10094050, PMID:9585406
For a more detailed mechanism see CRM1 in map Nucleus_MTOR

NFAT*|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​ubi|​ubi@Cytoplasm

References
s_wnc2_re72( Survival  map ):
Where exactly MDM2 ubiquitinates NFAT is not known and also not known if it is in the cytosol or nucleus.
PMID:16307918

NFAT*|​emp|​S289_pho|​S272_pho@Nucleus

References
s_wnc2_re85( Survival  map ):
S272 and S89 are PKA sites in NFAT3
PMID:10611249


Modifications:
In compartment: Cytoplasm
  1. NFAT*@Cytoplasm map

  2. NFAT*|​pho@Cytoplasm map
  3. NFAT*|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho@Cytoplasm map
  4. NFAT*|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​ubi|​ubi@Cytoplasm map

In compartment: Nucleus

  1. NFAT*@Nucleus map

  2. NFAT*@Nucleus map
  3. NFAT*@Nucleus map
  4. NFAT*|​pho|​pho@Nucleus map
  5. NFAT*|​emp|​S289_pho|​S272_pho@Nucleus map
  6. NFAT*|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho@Nucleus map

Participates in complexes:
In compartment: Cytoplasm

  1. HOMER3:​NFAT*|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho@Cytoplasm map

  2. Calmodulin*:​NFAT*:​PPP3R*@Cytoplasm map
  3. (NFAT*:​PPP3CB_sub_trunc_endsub_*:​PPP3R*)|​active@Cytoplasm map
  4. Calmodulin*:​NFAT*|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho:​PPP3R*@Cytoplasm map
  5. (NFAT*|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho:​PPP3CB_sub_trunc_endsub_*:​PPP3R*)|​active@Cytoplasm map
  6. Calmodulin*:​KPNB1:​NFAT*:​PPP3R*:​TNPO1:​Tubulin-_alpha_*@Cytoplasm map
  7. KPNB1:​NFAT*:​PPP3CB_sub_trunc_endsub_*:​PPP3R*:​TNPO1:​Tubulin-_alpha_*@Cytoplasm map
  8. CK1_epsilon_*:​DYRK*:​GSK3*:​IQGAP*:​NFAT*|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho:​NRON@Cytoplasm map
  9. CSE1L:​Calmodulin*:​KPNB1:​LRRK2:​NFAT*:​NRON:​PPP3R*:​TNPO1:​Tubulin-_alpha_*@Cytoplasm map
  10. CSE1L:​KPNB1:​LRRK2:​NFAT*:​NRON:​PPP3CB_sub_trunc_endsub_*:​PPP3R*:​TNPO1:​Tubulin-_alpha_*@Cytoplasm map

In compartment: Nucleus

  1. NF-_kappa_B:​NFAT*@Nucleus map

  2. CNA*:​CNB*:​NFAT*@Nucleus map
  3. GATA binding site*:​GATA*:​NFAT*@Nucleus map
  4. MEF2*:​NFAT*:​promoter binding site*@Nucleus map
  5. AP-1_ARRE binding sites*:​FOS:​JUN:​NFAT*@Nucleus map
  6. CNA*:​CNB*:​ERK2*:​MEK1*:​NFAT*@Nucleus map
  7. ERE:​ER_alpha_*:​FOXA*:​NFAT*:​estrogen@Nucleus map
  8. KPNB1:​NFAT*:​PPP3CB_sub_trunc_endsub_*:​PPP3R*:​Tubulin-_alpha_*@Nucleus map
  9. CNA*:​CNB*:​ERK2*:​MEK1*:​NFAT*|​pho@Nucleus map
  10. Ca2+:​Calmodulin*:​KPNB1:​NFAT*:​PPP3CB:​PPP3R*:​Tubulin-_alpha_*@Nucleus map

Participates in reactions:
As Reactant or Product:

  1. NFAT*@Cytoplasm map map NFAT*|​pho@Cytoplasm map

  2. NFAT*@Cytoplasm map map NFAT*@Nucleus map
  3. (PPP3CB_sub_trunc_endsub_*:​PPP3R*)|​active@Cytoplasm map + NFAT*|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho@Cytoplasm map map (NFAT*|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho:​PPP3CB_sub_trunc_endsub_*:​PPP3R*)|​active@Cytoplasm map
  4. (NFAT*|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho:​PPP3CB_sub_trunc_endsub_*:​PPP3R*)|​active@Cytoplasm map map (NFAT*:​PPP3CB_sub_trunc_endsub_*:​PPP3R*)|​active@Cytoplasm map
  5. KPNB1:​NFAT*:​PPP3CB_sub_trunc_endsub_*:​PPP3R*:​TNPO1:​Tubulin-_alpha_*@Cytoplasm map map KPNB1:​NFAT*:​PPP3CB_sub_trunc_endsub_*:​PPP3R*:​Tubulin-_alpha_*@Nucleus map
  6. Calmodulin*:​PPP3R*@Cytoplasm map + NFAT*|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho@Cytoplasm map map Calmodulin*:​NFAT*|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho:​PPP3R*@Cytoplasm map
  7. Calmodulin*:​NFAT*|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho:​PPP3R*@Cytoplasm map map Calmodulin*:​NFAT*:​PPP3R*@Cytoplasm map
  8. Calmodulin*:​KPNB1:​NFAT*:​PPP3R*:​TNPO1:​Tubulin-_alpha_*@Cytoplasm map map Ca2+:​Calmodulin*:​KPNB1:​NFAT*:​PPP3CB:​PPP3R*:​Tubulin-_alpha_*@Nucleus map
  9. Calmodulin*:​NFAT*:​PPP3R*@Cytoplasm map + KPNB1@Cytoplasm map + Tubulin-_alpha_*@Cytoplasm map + TNPO1@Cytoplasm map map Calmodulin*:​KPNB1:​NFAT*:​PPP3R*:​TNPO1:​Tubulin-_alpha_*@Cytoplasm map
  10. (NFAT*:​PPP3CB_sub_trunc_endsub_*:​PPP3R*)|​active@Cytoplasm map + KPNB1@Cytoplasm map + Tubulin-_alpha_*@Cytoplasm map + TNPO1@Cytoplasm map map KPNB1:​NFAT*:​PPP3CB_sub_trunc_endsub_*:​PPP3R*:​TNPO1:​Tubulin-_alpha_*@Cytoplasm map
  11. CK1_epsilon_*:​DYRK*:​GSK3*:​IQGAP*:​NFAT*|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho:​NRON@Cytoplasm map map NFAT*|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho@Cytoplasm map + IQGAP*@Cytoplasm map + DYRK*@Cytoplasm map + CK1_epsilon_*@Cytoplasm map + rNRON@Cytoplasm map + GSK3*@Cytoplasm map
  12. Calmodulin*:​KPNB1:​NFAT*:​PPP3R*:​TNPO1:​Tubulin-_alpha_*@Cytoplasm map + LRRK2@Cytoplasm map + rNRON@Cytoplasm map + CSE1L@Cytoplasm map map CSE1L:​Calmodulin*:​KPNB1:​LRRK2:​NFAT*:​NRON:​PPP3R*:​TNPO1:​Tubulin-_alpha_*@Cytoplasm map
  13. KPNB1:​NFAT*:​PPP3CB_sub_trunc_endsub_*:​PPP3R*:​TNPO1:​Tubulin-_alpha_*@Cytoplasm map + LRRK2@Cytoplasm map + CSE1L@Cytoplasm map + rNRON@Cytoplasm map map CSE1L:​KPNB1:​LRRK2:​NFAT*:​NRON:​PPP3CB_sub_trunc_endsub_*:​PPP3R*:​TNPO1:​Tubulin-_alpha_*@Cytoplasm map
  14. NFAT*|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho@Cytoplasm map + HOMER3@Cytoplasm map map HOMER3:​NFAT*|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho@Cytoplasm map
  15. NFAT*@Nucleus map map NFAT*|​pho|​pho@Nucleus map
  16. NFAT*|​pho|​pho@Nucleus map map NFAT*|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho@Nucleus map
  17. NFAT*|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho@Nucleus map map NFAT*|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho@Cytoplasm map
  18. NFAT*|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho@Cytoplasm map map CK1_epsilon_*:​DYRK*:​GSK3*:​IQGAP*:​NFAT*|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho:​NRON@Cytoplasm map
  19. Ca2+:​Calmodulin*:​KPNB1:​NFAT*:​PPP3CB:​PPP3R*:​Tubulin-_alpha_*@Nucleus map map NFAT*@Nucleus map + Tubulin-_alpha_*@Nucleus map + Ca2+:​Calmodulin*:​PPP3CB:​PPP3R*@Nucleus map + KPNB1@Nucleus map
  20. NFAT*|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho@Cytoplasm map map NFAT1*@Cytoplasm map
  21. NFAT*|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​ubi|​ubi@Cytoplasm map map degraded
  22. NFAT*|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho@Cytoplasm map map NFAT*|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​ubi|​ubi@Cytoplasm map
  23. (NFAT*:​PPP3CB_sub_trunc_endsub_*:​PPP3R*)|​active@Cytoplasm map map (NFAT*|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho:​PPP3CB_sub_trunc_endsub_*:​PPP3R*)|​active@Cytoplasm map
  24. NFAT*@Nucleus map map NFAT*|​emp|​S289_pho|​S272_pho@Nucleus map
  25. NFAT*|​emp|​S289_pho|​S272_pho@Nucleus map + 14-3-3*@Nucleus map map s_s_wnc2_s319
  26. estrogen@Nucleus map + ER_alpha_*@Nucleus map + gERE@Nucleus map + NFAT*@Nucleus map + FOXA*@Nucleus map map ERE:​ER_alpha_*:​FOXA*:​NFAT*:​estrogen@Nucleus map
  27. NFAT3*|​S676_pho@Nucleus map map NFAT*@Nucleus map
  28. NFAT1*|​unk|​unk@Nucleus map map NFAT*@Nucleus map
  29. NFAT1*|​gly@Nucleus map map NFAT*@Nucleus map
  30. CNA*:​CNB*:​NFAT*@Nucleus map map CNA*:​CNB*@Nucleus map + NFAT*@Nucleus map
  31. CNA*:​CNB*:​NFAT*@Nucleus map + ERK2*@Nucleus map + MEK1*@Nucleus map map CNA*:​CNB*:​ERK2*:​MEK1*:​NFAT*@Nucleus map
  32. CNA*:​CNB*:​ERK2*:​MEK1*:​NFAT*@Nucleus map map CNA*:​CNB*:​ERK2*:​MEK1*:​NFAT*|​pho@Nucleus map
  33. CNA*:​CNB*:​ERK2*:​MEK1*:​NFAT*|​pho@Nucleus map + gAP-1_ARRE binding sites*@Nucleus map + JUN@Nucleus map + FOS@Nucleus map map AP-1_ARRE binding sites*:​FOS:​JUN:​NFAT*@Nucleus map + CNA*:​CNB*@Nucleus map + ERK2*@Nucleus map + MEK1*@Nucleus map
  34. gAP-1_ARRE binding sites*@Nucleus map + JUN@Nucleus map + FOS@Nucleus map + NFAT*@Nucleus map map AP-1_ARRE binding sites*:​FOS:​JUN:​NFAT*@Nucleus map
  35. gNF-_kappa_B@Nucleus map + NFAT*@Nucleus map map NF-_kappa_B:​NFAT*@Nucleus map
  36. NFAT*@Nucleus map + GATA*@Nucleus map + gGATA binding site*@Nucleus map map GATA binding site*:​GATA*:​NFAT*@Nucleus map
  37. NFAT*@Nucleus map + MEF2*@Nucleus map + gpromoter binding site*@Nucleus map map MEF2*:​NFAT*:​promoter binding site*@Nucleus map

As Catalyser:

  1. gGPC6@Nucleus map map rGPC6@Nucleus map

  2. CNA*:​CNB*:​ERK2*:​MEK1*:​NFAT*|​pho@Nucleus map + gAP-1_ARRE binding sites*@Nucleus map + JUN@Nucleus map + FOS@Nucleus map map AP-1_ARRE binding sites*:​FOS:​JUN:​NFAT*@Nucleus map + CNA*:​CNB*@Nucleus map + ERK2*@Nucleus map + MEK1*@Nucleus map

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