NCKAP1

Protein NCKAP1 map

Identifiers
NCK-associated protein 1
HUGO:NCKAP1 HGNC:7666 ENTREZ:10787 UNIPROT:Q9Y2A7 GENECARDS:NCKAP1 REACTOME:59987 KEGG:10787 ATLASONC:GC_NCKAP1 WIKI:NCKAP1

Maps_Modules
 EMT  map  / EMT_REGULATORS  map
 EMT  map  / CYTOSKELETON_POLARITY  map

NCKAP1@Cytoplasm

References
e_re785( EMT  map ):
PMID:12181570
Rac1 binds to NCKAP1 and CYFIP2 and also promotes NCK1 binding to NCKAP1.
This binding inhibits NCKAP1 and CYFIP2 binding to WASF1 and promotes release of the complex of WASF1 and BRK1, thus activating WASF1.
Activated WASF1 then stimulates ARP2/3 that mediates actin cytoskeletal polymerizatioin
e_re802( EMT  map ):
Rac1 stimulates actin polymerization by activation of WAS protein family (WASF1 and WASF2)
PMID:16212495
PMID:9843499
PMID:16702231


Modifications:
In compartment: Cytoplasm
  1. NCKAP1@Cytoplasm map

Participates in complexes:
In compartment: Cytoplasm

  1. NCK1:​NCKAP1@Cytoplasm map

Participates in reactions:
As Reactant or Product:

  1. GTP:​RAC1@Cytoplasm map map NCKAP1@Cytoplasm map

  2. NCKAP1@Cytoplasm map map BNIP2@Cytoplasm map
  3. NCK1@Cytoplasm map + NCKAP1@Cytoplasm map map NCK1:​NCKAP1@Cytoplasm map

As Catalyser:

  1. WASF1@Cytoplasm map map WASF1@Cytoplasm map

Leave a Reply