NCK1:RAC1

Complex NCK1:RAC1 map


Complex composition:

  1. RAC1 map
  2. NCK1 map




NCK1:​RAC1@Cytoplasm

Identifiers
NAME:NCK1:RAC1

Maps_Modules
 EMT  map  / EMT_REGULATORS  map
 EMT  map  / CELL_CELL_ADHESIONS  map
 EMT  map  / TIGHT_JUNCTIONS  map
 EMT  map  / CYTOSKELETON_POLARITY  map

References
PMID:12181570
Rac1 binds to NCKAP1 and CYFIP2 and also promotes NCK1 binding to NCKAP1.
This binding inhibits NCKAP1 and CYFIP2 binding to WASF1 and promotes release of the complex of WASF1 and BRK1, thus activating WASF1.
Activated WASF1 then stimulates ARP2/3 that mediates actin cytoskeletal polymerizatioin

Confidence
REF=1 FUNC=5


Modifications:
Participates in complexes:
In compartment: Cytoplasm
  1. NCK1:​RAC1@Cytoplasm map

Participates in reactions:
As Reactant or Product:

  1. GTP:​RAC1@Cytoplasm map + NCK1@Cytoplasm map map NCK1:​RAC1@Cytoplasm map

As Catalyser:

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