NBS1*

Protein NBS1* map

Identifiers
nibrin
HUGO:NBN HGNC:7652 ENTREZ:4683 UNIPROT:O60934 GENECARDS:NBN REACTOME:75162 KEGG:4683 ATLASONC:NBS1ID160 WIKI:NBN

Maps_Modules
 Apoptosis  map  / MITOCH_METABOLISM  map
 DNA repair  map  / S_PHASE_CHECKPOINT  map
 DNA repair  map  / G2_M_CHECKPOINT  map
 DNA repair  map  / HR  map
 DNA repair  map  / A_NHEJ  map
 Cell cycle  map  / APOPTOSIS_ENTRY  map

References
synonym:NBS1
PMID:18809224, PMID:18584027, PMID:19772495, PMID:18087292, PMID:20723763
For S-phase checkpoint
PMID:15459660, PMID:11850621, PMID:19793801, PMID:12607003
For A_NHEJ (alt_NHEJ or B_NHEJ or MMEJ):
PMID:21376743, PMID:24050180, PMID:22743550

NBS1*@Site of DNA damage

References
a_re1477( Apoptosis  map ):
influenceDelete: re to reactants
PMID:18813293
review
through RAD50
a_re1478( Apoptosis  map ):
influenceDelete: re to products
PMID:18087291
review, more specifically retention of NBN
PMID:18001824
NBN interacts even with MDC1 mutated on its 3 phosphoacceptor sites

NBS1*@Nucleus

References
a_re1478( Apoptosis  map ):
influenceDelete: re to products
PMID:18087291
review, more specifically retention of NBN
PMID:18001824
NBN interacts even with MDC1 mutated on its 3 phosphoacceptor sites

NBS1*@default

References
d_re205( DNA repair  map ):
Phosphorylation of NBS1 by ATR in response to crosslink-activation of S phase checkpoint
PMID:15136767, PMID:14988723

NBS1*|​S343_pho@default

References
d_re205( DNA repair  map ):
Phosphorylation of NBS1 by ATR in response to crosslink-activation of S phase checkpoint
PMID:15136767, PMID:14988723
d_re91( DNA repair  map ):
MRN complex:
PMID:16531125, PMID:17303408
Double strand breaks sensor.
MRN complex association is a first event after the DNA damage.
d_re166( DNA repair  map ):
Fanconi recognition complex as FA core complex recruits NER, HR, TLS proteins that collectively repair the ICL. If Fanconi proteins participating in the recognition are dysactivated, there is no any other mechanism to recognize ILSs, therefore, even if NER, HR and TLS are correct, they will not perform the repair without core Fanconi proteins.
PMID:19686080
d_re187( DNA repair  map ):
PMID:18931676, PMID:19686080
Link between cell cycle and activation of Fanconi pathway
NBS1 is required for FANCD2 phosphorylation and relocation into the FA core complex:
PMID:14988723

NBS1*|​pho@Nucleus

References
c_re159:( Cell cycle  map ) PMID:12814430, PMID:12861053


Modifications:
In compartment: Nucleus
  1. NBS1*@Nucleus map

  2. NBS1*|​pho@Nucleus map

In compartment: Site of DNA damage

  1. NBS1*@Site of DNA damage map

In compartment: default

  1. NBS1*@default map

  2. NBS1*|​S343_pho@default map

Participates in complexes:
In compartment: Nucleus

  1. ATM|​Ser 1981_pho:​NBS1*|​pho@Nucleus map

  2. MRE11*:​NBS1*:​RAD50@Nucleus map
  3. ATM|​pho|​S367_pho|​S1893_pho:​CTIP*|​emp:​NBS1*|​S343_pho:​WRN@Nucleus map

In compartment: default

  1. MRE11*:​NBS1*|​S343_pho:​RAD50@default map

  2. ATM|​pho|​S367_pho|​S1893_pho:​MRE11*:​NBS1*|​S343_pho:​RAD50@default map
  3. ATR|​pho:​FANCD2|​K561_ubi|​pho:​MRE11*:​NBS1*|​S343_pho:​RAD50@default map
  4. ATM|​pho|​S367_pho|​S1893_pho:​H2AFX|​pho|​ubi:​MDC1|​pho:​MRE11*:​NBS1*|​S343_pho:​RAD50@default map
  5. BRCA1:​CTIP*|​emp|​S372_pho|​T847_pho|​S267_pho|​BRCA1-dep_ubi:​MRE11*:​NBS1*|​S343_pho:​PARP1|​PolyADPribose_unk|​pho:​PARP2|​unk|​pho:​RAD50@default map
  6. BRCA1:​BRCA2:​FANCD2|​pho:​FANCI|​pho:​H2AFX|​pho|​ubi:​NBS1*|​S343_pho:​PCNA:​RAD51:​TIP60*@default map
  7. BRCA1:​BRCA2:​FANCD2|​K561_ubi|​pho:​FANCI|​K523_ubi|​pho:​H2AFX|​pho|​ubi:​NBS1*|​S343_pho:​PCNA:​RAD51:​TIP60*@default map

Participates in reactions:
As Reactant or Product:

  1. MRE11*:​NBS1*:​RAD50@Nucleus map map RAD50@Site of DNA damage map + MRE11*@Site of DNA damage map + NBS1*@Site of DNA damage map

  2. NBS1*@Site of DNA damage map map NBS1*@Nucleus map
  3. NBS1*@Nucleus map + MRE11*@Nucleus map + RAD50@Nucleus map map MRE11*:​NBS1*:​RAD50@Nucleus map
  4. NBS1*@Nucleus map map NBS1*|​pho@Nucleus map
  5. ATM|​Ser 1981_pho@Nucleus map + NBS1*|​pho@Nucleus map map ATM|​Ser 1981_pho:​NBS1*|​pho@Nucleus map
  6. BRCA1|​S988_pho|​S1387_pho|​S1423_pho|​S1497_pho|​S1524_pho:​CTIP*|​emp|​S372_pho|​T847_pho|​S267_pho|​BRCA1-dep_ubi@default map + MRE11*:​NBS1*|​S343_pho:​RAD50@default map + PARP1|​PolyADPribose_unk|​pho:​PARP2|​unk|​pho@default map map BRCA1:​CTIP*|​emp|​S372_pho|​T847_pho|​S267_pho|​BRCA1-dep_ubi:​MRE11*:​NBS1*|​S343_pho:​PARP1|​PolyADPribose_unk|​pho:​PARP2|​unk|​pho:​RAD50@default map
  7. ATM|​pho|​S367_pho|​S1893_pho:​MRE11*:​NBS1*|​S343_pho:​RAD50@default map + CTIP*|​emp@default map + WRN@Nucleus map map ATM|​pho|​S367_pho|​S1893_pho:​CTIP*|​emp:​NBS1*|​S343_pho:​WRN@Nucleus map
  8. FANCD2|​K561_ubi|​pho:​FANCI|​K523_ubi|​pho@default map + BRCA1|​S988_pho|​S1387_pho|​S1423_pho|​S1497_pho|​S1524_pho|​active@default map + BRCA2@default map + NBS1*|​S343_pho@default map + RAD51@default map + PCNA@default map + H2AFX|​pho|​ubi@default map + TIP60*@default map map BRCA1:​BRCA2:​FANCD2|​K561_ubi|​pho:​FANCI|​K523_ubi|​pho:​H2AFX|​pho|​ubi:​NBS1*|​S343_pho:​PCNA:​RAD51:​TIP60*@default map
  9. NBS1*@default map map NBS1*|​S343_pho@default map
  10. FANCD2|​K561_ubi|​pho@default map + MRE11*:​NBS1*|​S343_pho:​RAD50@default map + ATR|​pho|​active@Nucleus map map ATR|​pho:​FANCD2|​K561_ubi|​pho:​MRE11*:​NBS1*|​S343_pho:​RAD50@default map
  11. BRCA1:​BRCA2:​FANCD2|​K561_ubi|​pho:​FANCI|​K523_ubi|​pho:​H2AFX|​pho|​ubi:​NBS1*|​S343_pho:​PCNA:​RAD51:​TIP60*@default map map BRCA1:​BRCA2:​FANCD2|​pho:​FANCI|​pho:​H2AFX|​pho|​ubi:​NBS1*|​S343_pho:​PCNA:​RAD51:​TIP60*@default map
  12. MRE11*@default map + RAD50@default map + NBS1*|​S343_pho@default map map MRE11*:​NBS1*|​S343_pho:​RAD50@default map
  13. ATM|​pho|​S367_pho|​S1893_pho:​MRE11*:​NBS1*|​S343_pho:​RAD50@default map + H2AFX|​pho|​ubi:​MDC1|​pho@default map map ATM|​pho|​S367_pho|​S1893_pho:​H2AFX|​pho|​ubi:​MDC1|​pho:​MRE11*:​NBS1*|​S343_pho:​RAD50@default map
  14. ATM|​pho|​S367_pho|​S1893_pho|​active@default map + MRE11*:​NBS1*|​S343_pho:​RAD50@default map map ATM|​pho|​S367_pho|​S1893_pho:​MRE11*:​NBS1*|​S343_pho:​RAD50@default map

As Catalyser:

  1. CHEK2@Nucleus map map CHEK2|​Thr68_pho@Nucleus map

  2. p53*@Nucleus map map p53*|​Ser15_pho@Nucleus map
  3. gA_NHEJ_DNA_st1*@Nucleus map map gA_NHEJ_DNA_st2*@Nucleus map
  4. gHR_DNA_st1*@Nucleus map map gHR_DNA_st2*@Nucleus map
  5. G1 phase@default map map S phase@default map
  6. S phase@default map map G2 phase@default map
  7. G2 phase@default map map M phase@default map
  8. gHR_DNA_st2*@Nucleus map map gHR_DNA_st3*@Nucleus map
  9. gFanconi_DNA_st2*@Nucleus map map gFanconi_DNA_st3*@Nucleus map
  10. gFanconi_DNA_st3*@Nucleus map map gFanconi_DNA_st4*@Nucleus map
  11. gFanconi_DNA_st4*@Nucleus map map gHR_DNA_st2*@Nucleus map
  12. FANCD2@default map map FANCD2|​pho@default map
  13. gSSA_DNA_st1*@Nucleus map map gSSA_DNA_st2*@Nucleus map
  14. ATM@default map map ATM|​pho|​S367_pho|​S1893_pho|​active@default map
  15. CHEK2@default map map CHEK2|​pho|​active@default map
  16. Ku70*@default map + Ku80*@default map map Ku70*:​Ku80*@Nucleus map
  17. gC_NHEJ_DNA_st1*@Nucleus map map gC_NHEJ_DNA_st2*@Nucleus map
  18. DNA-PK*@default map map DNA-PK*|​pho@default map
  19. H2AFX@default map map H2AFX|​pho@default map

Leave a Reply