MYC

Protein MYC map

Identifiers
v-myc myelocytomatosis viral oncogene homolog (avian)
HUGO:MYC HGNC:7553 ENTREZ:4609 UNIPROT:P01106 GENECARDS:MYC REACTOME:59773 KEGG:4609 ATLASONC:MYCID27 WIKI:MYC
“v-myc avian myelocytomatosis viral oncogene homolog”

Maps_Modules
 EMT  map  / EMT_REGULATORS  map
 Apoptosis  map  / APOPTOSIS_GENES  map
 DNA repair  map  / G1_S_CHECKPOINT  map
 Survival  map  / MAPK  map
 Survival  map  / WNT_NON_CANONICAL  map

References
PMID:11283614
Myc: an ubiquitous mediator of cell growth and proliferation
Myc can both activate and repress transcription, depending on the nature of associated factors
TGFB downregulates Myc to cause cell cycle arrest.
TGFB activates p15INK4B and/or p21CIP1 (inhibitor of CDKs) ==> CDK inhibition by TGFB
TGFB downregulates cdc25A (a phosphatase, activator of CDKs) ==> CDK inhibition by TGFB
PMID:20551172, PMID:21406394, PMID:17873522, PMID:17558397
C-MYC is a key regulator of cell proliferation differentiaton and apoptosis. The biological functions of C-MYC are thought to depend in part on the polypeptide binding partners with which it interacts.
PMID:11274345

MYC@Nucleus

References
e_re280( EMT  map ):
PMID:11283613
Miz-1 regulates expression of p15INK4b
A Myc–Miz-1 complex binds to the p15 promoter
Myc inhibits binding of p300 to Miz-1
Myc inhibits expression of p15INK4B by binding to Miz-1 (Myc represses p15INK4B by interacting with Miz1)
PMID:11283614
Miz1: a Myc-interacting Zinc-finger protein that recognizes certain transcriptional initiator elements
One of this transcriptional initiator element contains the sequence 5′-CCCACTCTGC corresponding to the p15INK4B transcriptional intiator

MYC|​ace@default

References
d_re404( DNA repair  map ):
Acetylation of c-Myc keeps it inactive and prevents G1/S propagation
PMID:15522869

MYC@default

References
d_re404( DNA repair  map ):
Acetylation of c-Myc keeps it inactive and prevents G1/S propagation
PMID:15522869
d_re405( DNA repair  map ):
p107 interacts with c-Myc and inhibits c-Myc activity and G1/S propagation:
PMID:8076603

MYC|​S62_pho@Nucleus

References
s_wnc4_re13:( Survival  map ) PMID:19131971

MYC|​S62_emp|​T58_pho@Nucleus

References
s_wnc4_re17:( Survival  map ) PMID:16969074

MYC|​S62_emp|​T58_pho|​K63_ubi@Nucleus

References
s_wnc4_re17:( Survival  map ) PMID:16969074


Modifications:
In compartment: Nucleus
  1. MYC@Nucleus map

  2. MYC|​S62_pho@Nucleus map
  3. MYC|​S62_emp|​T58_pho@Nucleus map
  4. MYC|​S62_emp|​T58_pho|​K63_ubi@Nucleus map

In compartment: default

  1. MYC@default map

  2. MYC|​ace@default map

Participates in complexes:
In compartment: Nucleus

  1. MIZ1*:​MYC@Nucleus map

  2. AXIN1:​GSK3*:​MYC|​S62_pho:​PIN1@Nucleus map
  3. AXIN1:​GSK3*:​MYC|​S62_emp|​T58_pho:​PIN1@Nucleus map
  4. AXIN1:​GSK3*:​MYC|​S62_pho|​T58_pho:​PIN1@Nucleus map

In compartment: default

  1. MAX:​MYC@default map

  2. MYC:​p107*@default map
  3. (MIZ1*:​MYC:​PKMYT1|​pho)|​active@default map

Participates in reactions:
As Reactant or Product:

  1. rMYC@Nucleus map map MYC@Nucleus map

  2. MYC@Nucleus map + p14ARF*@Nucleus map map a_s3238
  3. a_s3297 map MYC@Nucleus map
  4. MAX@Nucleus map + MYC@Nucleus map map a_s3297
  5. MAX@default map + MYC@default map map MAX:​MYC@default map
  6. MYC@default map + MIZ1*@default map + PKMYT1@Nucleus map map (MIZ1*:​MYC:​PKMYT1|​pho)|​active@default map
  7. MYC@default map map MYC|​ace@default map
  8. MYC@default map + p107*@default map map MYC:​p107*@default map
  9. rMYC@Nucleus map map MYC@Nucleus map
  10. MIZ1*@Nucleus map + MYC@Nucleus map map MIZ1*:​MYC@Nucleus map
  11. MYC@Nucleus map map gp14INK4A*@Nucleus map
  12. gMYC@Nucleus map map MYC@Nucleus map
  13. MYC@Nucleus map map Proliferation@Cytoplasm map
  14. MYC|​S62_pho@Nucleus map map Cell cycle pathway@Nucleus map
  15. MYC|​S62_pho@Nucleus map + AXIN1@Nucleus map + GSK3*@Nucleus map + PIN1@Nucleus map map AXIN1:​GSK3*:​MYC|​S62_pho:​PIN1@Nucleus map
  16. AXIN1:​GSK3*:​MYC|​S62_pho:​PIN1@Nucleus map map AXIN1:​GSK3*:​MYC|​S62_pho|​T58_pho:​PIN1@Nucleus map
  17. AXIN1:​GSK3*:​MYC|​S62_pho|​T58_pho:​PIN1@Nucleus map map AXIN1:​GSK3*:​MYC|​S62_emp|​T58_pho:​PIN1@Nucleus map
  18. AXIN1:​GSK3*:​MYC|​S62_emp|​T58_pho:​PIN1@Nucleus map map MYC|​S62_emp|​T58_pho@Nucleus map + AXIN1@Nucleus map + PIN1@Nucleus map + GSK3*@Nucleus map
  19. MYC|​S62_emp|​T58_pho@Nucleus map map MYC|​S62_emp|​T58_pho|​K63_ubi@Nucleus map
  20. MYC|​S62_emp|​T58_pho|​K63_ubi@Nucleus map map degraded

As Catalyser:

  1. gCFLAR@Nucleus map map rCFLAR@Nucleus map

  2. p14ARF*@Nucleus map map p14ARF*|​ubi@Nucleus map
  3. gCDKN2A@Nucleus map map rp14ARF*@Nucleus map
  4. gMIR17-92*@Nucleus map map arMIR17-92*@Nucleus map
  5. gPDK1@Nucleus map map rPDK1@Nucleus map
  6. gGPI@Nucleus map map rGPI@Nucleus map
  7. gTPI1@Nucleus map map rTPI1@Nucleus map
  8. gLDHA@Nucleus map map rLDHA@Nucleus map
  9. gGAPDH@Nucleus map map rGAPDH@Nucleus map
  10. gPFKM@Nucleus map map rPFKM@Nucleus map
  11. gNDUFAF2@Nucleus map map rNDUFAF2@Nucleus map
  12. gCaspase8*@Nucleus map map rCaspase8*@Nucleus map
  13. gSLC38A5@Nucleus map map rSLC38A5@Nucleus map
  14. gSLC1A5@Nucleus map map rSLC1A5@Nucleus map
  15. gMIR23A@Nucleus map map arMIR23A@Cytoplasm map
  16. gAPO*@Nucleus map map rpre-mRNA~APO*@Nucleus map
  17. gPRDX3@Nucleus map map rPRDX3@Nucleus map
  18. gCytochrome_C*@Nucleus map map rCytochrome_C*@Nucleus map
  19. gMismatched_nucleotide*@Nucleus map map gMMR_DNA_st2*@Nucleus map
  20. gINK4*@default map map rINK4*@default map
  21. gCyclinD*@default map map rCyclinD*@default map
  22. gCDC25A@default map map rCDC25A@default map
  23. gPTP4A3@Nucleus map map rPTP4A3@Nucleus map
  24. gp15INK4B*@Nucleus map map rp15INK4B*@Nucleus map
  25. gp21CIP1*@Nucleus map map rp21CIP1*@Nucleus map

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