MTOR

Protein MTOR map

Identifiers
mechanistic target of rapamycin (serine/threonine kinase)
HUGO:MTOR HGNC:3942 ENTREZ:2475 UNIPROT:P42345 GENECARDS:MTOR REACTOME:54978 KEGG:2475 ATLASONC:FRAP1ID40639ch1p36 WIKI:MTOR

Maps_Modules
 Apoptosis  map  / AKT_MTOR  map
 Apoptosis  map  / APOPTOSIS_GENES  map
 Survival  map  / PI3K_AKT_MTOR  map

References
synonym:FRAP1
PMID:19568798
PMID:17680028
PMID:21157483

MTOR@Cytoplasm

References
a_re1418( Apoptosis  map ):
PMID:20501828
by the 3p mature isoform of MIR199A
a_re371( Apoptosis  map ):
influenceDelete: re to reactants
engagement of mTOR in mTORC1 does not titrate it out of mTORC2
a_re1038( Apoptosis  map ):
engagement of mTOR in mTORC2 does not titrate it out of mTORC1

MTOR|​S2448_pho@Cytoplasm

References
s_akt1_re110:( Survival  map ) PMID:15905173

MTOR|​Y631_ubi@Cytoplasm

References
s_akt1_re184:( Survival  map ) PMID:18787170


Modifications:
In compartment: Cytoplasm
  1. MTOR@Cytoplasm map

  2. MTOR|​Y631_ubi@Cytoplasm map
  3. MTOR|​S2448_pho@Cytoplasm map

Participates in complexes:
In compartment: Cytoplasm

  1. (MTOR|​S1261_pho|​S2481_pho:​RPTOR|​S696_pho|​T706_pho|​S855_pho|​S863_pho|​S877_pho|​S859_pho)|​active@Cytoplasm map

  2. MLST8:​MTOR:​RPTOR@Cytoplasm map
  3. MLST8:​MTOR:​RPTOR|​pho@Cytoplasm map
  4. MLST8:​MTOR:​RPTOR|​unk@Cytoplasm map
  5. MLST8:​MTOR:​PRAS40*:​RPTOR@Cytoplasm map
  6. MAPKAP1:​MLST8:​MTOR:​RICTOR@Cytoplasm map
  7. FKBP8:​MLST8:​MTOR:​RPTOR|​unk@Cytoplasm map
  8. DEPDC6:​MLST8:​MTOR:​RPTOR|​unk@Cytoplasm map
  9. MLST8:​MTOR:​PRAS40*|​pho:​RPTOR@Cytoplasm map
  10. DEPDC6:​MAPKAP1:​MLST8:​MTOR:​RICTOR@Cytoplasm map
  11. EIF3*:​EIF4E*:​M7GTP*:​MTOR|​S1261_pho|​S2448_emp|​S2481_pho:​RPTOR|​S696_pho|​T706_pho|​S855_pho|​S863_pho|​S877_pho|​S859_pho:​mRNA generic*@Cytoplasm map
  12. EIF3*:​EIF4E*:​M7GTP*:​MTOR|​S1261_pho|​S2448_emp|​S2481_pho:​RPTOR|​S696_pho|​T706_pho|​S855_pho|​S863_pho|​S877_pho|​S859_pho:​mRNA generic*:​p70_alpha_*|​T389_pho@Cytoplasm map
  13. EIF3*:​EIF4A*:​EIF4B|​pho:​EIF4E*:​EIF4G*:​M7GTP*:​MTOR|​S1261_pho|​S2448_emp|​S2481_pho:​PABP1*:​RPS6|​S235_pho|​S236_pho|​S240_pho|​S244_pho|​S247_pho:​RPTOR|​S696_pho|​T706_pho|​S855_pho|​S863_pho|​S877_pho|​S859_pho:​mRNA generic*@Cytoplasm map

In compartment: Lipid Raft

  1. MAPKAP1:​MLST8:​MTOR|​S2481_pho:​PROTOR*:​RAC1:​RICTOR@Lipid Raft map

  2. MAPKAP1:​MLST8:​MTOR|​S2481_pho:​PROTOR*:​RAC1:​RICTOR|​T1135_pho@Lipid Raft map
  3. 14-3-3*:​MAPKAP1:​MLST8:​MTOR|​S2481_pho:​PROTOR*:​RICTOR|​T1135_pho@Lipid Raft map
  4. DEPTOR:​MAPKAP1:​MLST8:​MTOR|​S2481_pho:​PROTOR*:​RAC1:​RICTOR@Lipid Raft map

In compartment: Membrane Lysosome

  1. MLST8:​MTOR|​S1261_pho|​S2448_emp|​S2481_pho:​RAC1:​RPTOR|​S696_pho|​T706_pho|​S855_pho|​S863_pho|​S877_pho|​S859_pho@Membrane Lysosome map

  2. MLST8:​MTOR|​S2448_emp:​PRAS40*:​RAC1:​RPTOR@Membrane Lysosome map
  3. MLST8:​MTOR|​S2448_pho:​PRAS40*:​RAC1:​RPTOR@Membrane Lysosome map
  4. MLST8:​MTOR|​S1261_pho|​S2448_emp:​PRAS40*:​RAC1:​RPTOR@Membrane Lysosome map
  5. MLST8:​MTOR|​S1261_pho|​S2448_emp|​S2481_pho:​PRAS40*:​RAC1:​RPTOR@Membrane Lysosome map
  6. DEPTOR:​MLST8:​MTOR|​S1261_pho|​S2448_emp|​S2481_pho:​RAC1:​RPTOR|​S696_pho|​T706_pho|​S855_pho|​S863_pho|​S877_pho|​S859_pho@Membrane Lysosome map
  7. MLST8:​MTOR|​S1261_pho|​S2448_emp|​S2481_pho:​PRAS40*|​S183_emp|​T246_emp:​RAC1:​RPTOR|​S696_pho|​T706_pho|​S863_pho|​S877_pho@Membrane Lysosome map
  8. MLST8:​MTOR|​S1261_pho|​S2448_emp|​S2481_pho:​PRAS40*|​S183_emp|​T246_emp:​RAC1:​RPTOR|​S696_pho|​T706_pho|​S855_pho|​S863_pho|​S877_pho|​S859_pho@Membrane Lysosome map
  9. MLST8:​MTOR|​S1261_pho|​S2448_emp|​S2481_pho:​PRAS40*|​S183_pho|​T246_pho|​S212_pho|​S221_pho:​RAC1:​RPTOR|​S696_pho|​T706_pho|​S855_pho|​S863_pho|​S877_pho|​S859_pho@Membrane Lysosome map

In compartment: Nucleus

  1. MLST8:​MTOR:​RPTOR|​unk@Nucleus map

  2. MLST8:​MTOR:​PPARGC1A:​RPTOR|​pho:​YY1@Nucleus map

In compartment: PML Body

  1. MLST8:​MTOR:​RPTOR|​unk@PML Body map

Participates in reactions:
As Reactant or Product:

  1. MAPKAP1@Cytoplasm map + RICTOR@Cytoplasm map + MLST8@Cytoplasm map + MTOR@Cytoplasm map map MAPKAP1:​MLST8:​MTOR:​RICTOR@Cytoplasm map

  2. rMTOR@Nucleus map map MTOR@Cytoplasm map
  3. DEPDC6@Cytoplasm map + MLST8:​MTOR:​RPTOR|​unk@Cytoplasm map map DEPDC6:​MLST8:​MTOR:​RPTOR|​unk@Cytoplasm map
  4. MAPKAP1:​MLST8:​MTOR:​RICTOR@Cytoplasm map + DEPDC6@Cytoplasm map map DEPDC6:​MAPKAP1:​MLST8:​MTOR:​RICTOR@Cytoplasm map
  5. MLST8:​MTOR:​RPTOR@Cytoplasm map + PRAS40*@Cytoplasm map map MLST8:​MTOR:​PRAS40*:​RPTOR@Cytoplasm map
  6. MLST8:​MTOR:​PRAS40*:​RPTOR@Cytoplasm map map MLST8:​MTOR:​PRAS40*|​pho:​RPTOR@Cytoplasm map
  7. 14-3-3*|​unk@Cytoplasm map + MLST8:​MTOR:​PRAS40*|​pho:​RPTOR@Cytoplasm map map MLST8:​MTOR:​RPTOR@Cytoplasm map + 14-3-3*|​unk:​PRAS40*|​pho@Cytoplasm map
  8. MLST8@Cytoplasm map + MTOR@Cytoplasm map + RPTOR@Cytoplasm map map MLST8:​MTOR:​RPTOR@Cytoplasm map
  9. MLST8:​MTOR:​RPTOR@Cytoplasm map map MLST8:​MTOR:​RPTOR|​pho@Cytoplasm map
  10. MLST8:​MTOR:​RPTOR|​unk@Cytoplasm map map MLST8:​MTOR:​RPTOR|​unk@Cytoplasm map
  11. MLST8:​MTOR:​RPTOR|​unk@Cytoplasm map map MLST8:​MTOR:​RPTOR|​unk@Nucleus map
  12. MLST8:​MTOR:​RPTOR|​unk@Cytoplasm map map MLST8:​MTOR:​RPTOR|​pho@Cytoplasm map
  13. MLST8:​MTOR:​RPTOR|​unk@Nucleus map map MLST8:​MTOR:​RPTOR|​unk@PML Body map
  14. YY1@Nucleus map + PPARGC1A@Nucleus map + MLST8:​MTOR:​RPTOR|​unk@Nucleus map map MLST8:​MTOR:​PPARGC1A:​RPTOR|​pho:​YY1@Nucleus map
  15. MLST8:​MTOR:​RPTOR@Cytoplasm map map MLST8:​MTOR:​RPTOR|​unk@Cytoplasm map
  16. MLST8:​MTOR:​RPTOR|​pho@Cytoplasm map map MLST8:​MTOR:​RPTOR|​unk@Cytoplasm map
  17. MLST8:​MTOR:​RPTOR|​unk@Cytoplasm map + FKBP8@Cytoplasm map map FKBP8:​MLST8:​MTOR:​RPTOR|​unk@Cytoplasm map
  18. MTOR@Cytoplasm map map MTOR|​S2448_pho@Cytoplasm map
  19. PRAS40*@Cytoplasm map + MLST8@Cytoplasm map + RPTOR@Cytoplasm map + MTOR|​S2448_pho@Cytoplasm map map MLST8:​MTOR|​S2448_pho:​PRAS40*:​RAC1:​RPTOR@Membrane Lysosome map
  20. PRAS40*@Cytoplasm map + MLST8@Cytoplasm map + RPTOR@Cytoplasm map + MTOR@Cytoplasm map + RAC1@Cytoplasm map map s_s_akt1_s873
  21. DEPTOR@Cytoplasm map + MAPKAP1:​MLST8:​MTOR|​S2481_pho:​PROTOR*:​RAC1:​RICTOR@Lipid Raft map map DEPTOR:​MAPKAP1:​MLST8:​MTOR|​S2481_pho:​PROTOR*:​RAC1:​RICTOR@Lipid Raft map
  22. 14-3-3*:​MAPKAP1:​MLST8:​MTOR|​S2481_pho:​PROTOR*:​RICTOR|​T1135_pho@Lipid Raft map map PROTOR*:​RICTOR|​T1135_pho@Cytoplasm map
  23. s_s_akt1_s864 map MAPKAP1:​MLST8:​MTOR|​S2481_pho:​PROTOR*:​RAC1:​RICTOR@Lipid Raft map
  24. MTOR@Cytoplasm map map MTOR|​Y631_ubi@Cytoplasm map
  25. s_s_akt1_s873 map MLST8:​MTOR|​S2448_emp:​PRAS40*:​RAC1:​RPTOR@Membrane Lysosome map
  26. MLST8:​MTOR|​S2448_emp:​PRAS40*:​RAC1:​RPTOR@Membrane Lysosome map map MLST8:​MTOR|​S1261_pho|​S2448_emp:​PRAS40*:​RAC1:​RPTOR@Membrane Lysosome map
  27. MLST8:​MTOR|​S1261_pho|​S2448_emp:​PRAS40*:​RAC1:​RPTOR@Membrane Lysosome map map MLST8:​MTOR|​S1261_pho|​S2448_emp|​S2481_pho:​PRAS40*:​RAC1:​RPTOR@Membrane Lysosome map
  28. MLST8:​MTOR|​S1261_pho|​S2448_emp|​S2481_pho:​PRAS40*:​RAC1:​RPTOR@Membrane Lysosome map map MLST8:​MTOR|​S1261_pho|​S2448_emp|​S2481_pho:​PRAS40*|​S183_emp|​T246_emp:​RAC1:​RPTOR|​S696_pho|​T706_pho|​S863_pho|​S877_pho@Membrane Lysosome map
  29. MLST8:​MTOR|​S1261_pho|​S2448_emp|​S2481_pho:​PRAS40*|​S183_emp|​T246_emp:​RAC1:​RPTOR|​S696_pho|​T706_pho|​S863_pho|​S877_pho@Membrane Lysosome map map MLST8:​MTOR|​S1261_pho|​S2448_emp|​S2481_pho:​PRAS40*|​S183_emp|​T246_emp:​RAC1:​RPTOR|​S696_pho|​T706_pho|​S855_pho|​S863_pho|​S877_pho|​S859_pho@Membrane Lysosome map
  30. MLST8:​MTOR|​S1261_pho|​S2448_emp|​S2481_pho:​PRAS40*|​S183_emp|​T246_emp:​RAC1:​RPTOR|​S696_pho|​T706_pho|​S855_pho|​S863_pho|​S877_pho|​S859_pho@Membrane Lysosome map map MLST8:​MTOR|​S1261_pho|​S2448_emp|​S2481_pho:​PRAS40*|​S183_pho|​T246_pho|​S212_pho|​S221_pho:​RAC1:​RPTOR|​S696_pho|​T706_pho|​S855_pho|​S863_pho|​S877_pho|​S859_pho@Membrane Lysosome map
  31. MLST8:​MTOR|​S1261_pho|​S2448_emp|​S2481_pho:​PRAS40*|​S183_pho|​T246_pho|​S212_pho|​S221_pho:​RAC1:​RPTOR|​S696_pho|​T706_pho|​S855_pho|​S863_pho|​S877_pho|​S859_pho@Membrane Lysosome map map MLST8:​MTOR|​S1261_pho|​S2448_emp|​S2481_pho:​RAC1:​RPTOR|​S696_pho|​T706_pho|​S855_pho|​S863_pho|​S877_pho|​S859_pho@Membrane Lysosome map + PRAS40*|​S183_pho|​T246_pho|​S212_pho|​S221_pho@Membrane Lysosome map
  32. DEPTOR@Cytoplasm map map MLST8:​MTOR|​S1261_pho|​S2448_emp|​S2481_pho:​RAC1:​RPTOR|​S696_pho|​T706_pho|​S855_pho|​S863_pho|​S877_pho|​S859_pho@Membrane Lysosome map + DEPTOR:​MLST8:​MTOR|​S1261_pho|​S2448_emp|​S2481_pho:​RAC1:​RPTOR|​S696_pho|​T706_pho|​S855_pho|​S863_pho|​S877_pho|​S859_pho@Membrane Lysosome map
  33. MLST8:​MTOR|​S1261_pho|​S2448_emp|​S2481_pho:​RAC1:​RPTOR|​S696_pho|​T706_pho|​S855_pho|​S863_pho|​S877_pho|​S859_pho@Membrane Lysosome map map (MTOR|​S1261_pho|​S2481_pho:​RPTOR|​S696_pho|​T706_pho|​S855_pho|​S863_pho|​S877_pho|​S859_pho)|​active@Cytoplasm map
  34. (MTOR|​S1261_pho|​S2481_pho:​RPTOR|​S696_pho|​T706_pho|​S855_pho|​S863_pho|​S877_pho|​S859_pho)|​active@Cytoplasm map + EIF3*:​EIF4E*:​M7GTP*:​mRNA generic*:​p70_alpha_*@Cytoplasm map map EIF3*:​EIF4E*:​M7GTP*:​MTOR|​S1261_pho|​S2448_emp|​S2481_pho:​RPTOR|​S696_pho|​T706_pho|​S855_pho|​S863_pho|​S877_pho|​S859_pho:​mRNA generic*:​p70_alpha_*|​T389_pho@Cytoplasm map
  35. EIF3*:​EIF4E*:​M7GTP*:​MTOR|​S1261_pho|​S2448_emp|​S2481_pho:​RPTOR|​S696_pho|​T706_pho|​S855_pho|​S863_pho|​S877_pho|​S859_pho:​mRNA generic*:​p70_alpha_*|​T389_pho@Cytoplasm map map EIF3*:​EIF4E*:​M7GTP*:​MTOR|​S1261_pho|​S2448_emp|​S2481_pho:​RPTOR|​S696_pho|​T706_pho|​S855_pho|​S863_pho|​S877_pho|​S859_pho:​mRNA generic*@Cytoplasm map + p70_alpha_*|​T389_pho@Cytoplasm map + 4E-BP*|​T37_pho|​T46_pho|​S65_pho|​T70_pho@Cytoplasm map
  36. EIF3*:​EIF4E*:​M7GTP*:​MTOR|​S1261_pho|​S2448_emp|​S2481_pho:​RPTOR|​S696_pho|​T706_pho|​S855_pho|​S863_pho|​S877_pho|​S859_pho:​mRNA generic*@Cytoplasm map + RPS6|​S235_pho|​S236_pho|​S240_pho|​S244_pho|​S247_pho@Cytoplasm map + EIF4B|​S422_pho@Cytoplasm map + EIF4G*@Cytoplasm map + PABP1*@Cytoplasm map + EIF4A*@Cytoplasm map map EIF3*:​EIF4A*:​EIF4B|​pho:​EIF4E*:​EIF4G*:​M7GTP*:​MTOR|​S1261_pho|​S2448_emp|​S2481_pho:​PABP1*:​RPS6|​S235_pho|​S236_pho|​S240_pho|​S244_pho|​S247_pho:​RPTOR|​S696_pho|​T706_pho|​S855_pho|​S863_pho|​S877_pho|​S859_pho:​mRNA generic*@Cytoplasm map
  37. EIF3*:​EIF4A*:​EIF4B|​pho:​EIF4E*:​EIF4G*:​M7GTP*:​MTOR|​S1261_pho|​S2448_emp|​S2481_pho:​PABP1*:​RPS6|​S235_pho|​S236_pho|​S240_pho|​S244_pho|​S247_pho:​RPTOR|​S696_pho|​T706_pho|​S855_pho|​S863_pho|​S877_pho|​S859_pho:​mRNA generic*@Cytoplasm map map mRNA translation@Cytoplasm map
  38. MAPKAP1:​MLST8:​MTOR|​S2481_pho:​PROTOR*:​RAC1:​RICTOR@Lipid Raft map map MAPKAP1:​MLST8:​MTOR|​S2481_pho:​PROTOR*:​RAC1:​RICTOR|​T1135_pho@Lipid Raft map
  39. MAPKAP1:​MLST8:​MTOR|​S2481_pho:​PROTOR*:​RAC1:​RICTOR|​T1135_pho@Lipid Raft map + 14-3-3*@Lipid Raft map map 14-3-3*:​MAPKAP1:​MLST8:​MTOR|​S2481_pho:​PROTOR*:​RICTOR|​T1135_pho@Lipid Raft map

As Catalyser:

  1. DEPDC6@Cytoplasm map map DEPDC6|​pho@Cytoplasm map

  2. rHIF1A@Nucleus map map HIF1A@Cytoplasm map
  3. AKT*@Cytoplasm map map AKT*|​S473_pho|​T308_pho@Cytoplasm map
  4. MLST8:​MTOR:​PRAS40*:​RPTOR@Cytoplasm map map MLST8:​MTOR:​PRAS40*|​pho:​RPTOR@Cytoplasm map
  5. degraded map Autophagy@Cytoplasm map
  6. S6K*@Cytoplasm map map S6K*|​pho@Cytoplasm map
  7. 4E-BP*@Cytoplasm map map 4E-BP*|​pho@Cytoplasm map
  8. gCytochrome_C*@Nucleus map map rCytochrome_C*@Nucleus map
  9. gPPARGC1A@Nucleus map map rPPARGC1A@Nucleus map
  10. gESRRA@Nucleus map map rESRRA@Nucleus map
  11. gNRF1@Nucleus map map rNRF1@Nucleus map
  12. gPPARGC1B@Nucleus map map rPPARGC1B@Nucleus map
  13. gATP5G1@Nucleus map map rATP5G1@Nucleus map
  14. gCOX5A@Nucleus map map rCOX5A@Nucleus map
  15. gIDH3A@Nucleus map map rIDH3A@Nucleus map
  16. gPHLPP*@Nucleus map map rPHLPP*@Nucleus map
  17. p70_beta_*@Cytoplasm map map p70_beta_*|​pho@Cytoplasm map
  18. ATG13:​FIP200*:​ULK*@Cytoplasm map map ATG13|​pho:​FIP200*:​ULK*|​pho@Cytoplasm map
  19. AKT1|​T308_pho|​T450_pho|​S473_emp:​PI3,4,5-P3@Lipid Raft map map AKT1|​T308_pho|​T450_pho|​S473_pho:​PI3,4,5-P3@Lipid Raft map
  20. AKT1|​T450_emp|​S473_emp|​S129_emp@Cytoplasm map map AKT1|​T450_pho|​S473_emp|​active@Cytoplasm map
  21. MLST8:​MTOR|​S1261_pho|​S2448_emp:​PRAS40*:​RAC1:​RPTOR@Membrane Lysosome map map MLST8:​MTOR|​S1261_pho|​S2448_emp|​S2481_pho:​PRAS40*:​RAC1:​RPTOR@Membrane Lysosome map
  22. MLST8:​MTOR|​S1261_pho|​S2448_emp|​S2481_pho:​PRAS40*:​RAC1:​RPTOR@Membrane Lysosome map map MLST8:​MTOR|​S1261_pho|​S2448_emp|​S2481_pho:​PRAS40*|​S183_emp|​T246_emp:​RAC1:​RPTOR|​S696_pho|​T706_pho|​S863_pho|​S877_pho@Membrane Lysosome map
  23. MLST8:​MTOR|​S1261_pho|​S2448_emp|​S2481_pho:​PRAS40*|​S183_emp|​T246_emp:​RAC1:​RPTOR|​S696_pho|​T706_pho|​S855_pho|​S863_pho|​S877_pho|​S859_pho@Membrane Lysosome map map MLST8:​MTOR|​S1261_pho|​S2448_emp|​S2481_pho:​PRAS40*|​S183_pho|​T246_pho|​S212_pho|​S221_pho:​RAC1:​RPTOR|​S696_pho|​T706_pho|​S855_pho|​S863_pho|​S877_pho|​S859_pho@Membrane Lysosome map
  24. MLST8:​MTOR|​S1261_pho|​S2448_emp|​S2481_pho:​PRAS40*|​S183_pho|​T246_pho|​S212_pho|​S221_pho:​RAC1:​RPTOR|​S696_pho|​T706_pho|​S855_pho|​S863_pho|​S877_pho|​S859_pho@Membrane Lysosome map map MLST8:​MTOR|​S1261_pho|​S2448_emp|​S2481_pho:​RAC1:​RPTOR|​S696_pho|​T706_pho|​S855_pho|​S863_pho|​S877_pho|​S859_pho@Membrane Lysosome map + PRAS40*|​S183_pho|​T246_pho|​S212_pho|​S221_pho@Membrane Lysosome map
  25. (MTOR|​S1261_pho|​S2481_pho:​RPTOR|​S696_pho|​T706_pho|​S855_pho|​S863_pho|​S877_pho|​S859_pho)|​active@Cytoplasm map + EIF3*:​EIF4E*:​M7GTP*:​mRNA generic*:​p70_alpha_*@Cytoplasm map map EIF3*:​EIF4E*:​M7GTP*:​MTOR|​S1261_pho|​S2448_emp|​S2481_pho:​RPTOR|​S696_pho|​T706_pho|​S855_pho|​S863_pho|​S877_pho|​S859_pho:​mRNA generic*:​p70_alpha_*|​T389_pho@Cytoplasm map
  26. SGK1@Cytoplasm map map SGK1|​S442_pho@Cytoplasm map

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