MT-CO2

Protein MT-CO2 map

Identifiers
mitochondrially encoded cytochrome c oxidase II
HUGO:MT-CO2 HGNC:7421 ENTREZ:4513 UNIPROT:P00403 GENECARDS:MT-CO2 REACTOME:52588 ATLASONC:GC_COX2 WIKI:MT-CO2

Maps_Modules
 Apoptosis  map  / APOPTOSIS_GENES  map
 Apoptosis  map  / MITOCH_METABOLISM  map

MT-CO2@Mitochondrial inner membrane

References
a_re1111( Apoptosis  map ):
PMID:15229189
SCO1, SCO2, and COX17 act cooperatively to load MT-CO2 with copper (copper chaperones)
PMID:19393246
in Hela, COX17 siRNA interferes with copper loading into MT-CO2
PMID:18458339
detailed description of COX17 mediated copper loading of SCO proteins, and interactions with the disulfide based modifications of these proteins


Modifications:
In compartment: Mitochondrial inner membrane
  1. MT-CO2@Mitochondrial inner membrane map

Participates in complexes:
In compartment: Mitochondrial inner membrane

  1. Cu2+:​MT-CO2@Mitochondrial inner membrane map

  2. COX4I1:​COX5A:​COX5B:​COX6A*:​COX6B*:​COX6C:​COX7A*:​COX7B*:​COX7C:​COX8*:​Cu2+:​MT-CO1:​MT-CO2:​MT-CO3:​heme a@Mitochondrial inner membrane map
  3. COX4I2:​COX5A:​COX5B:​COX6A*:​COX6B*:​COX6C:​COX7A*:​COX7B*:​COX7C:​COX8*:​Cu2+:​MT-CO1:​MT-CO2:​MT-CO3:​heme a@Mitochondrial inner membrane map

Participates in reactions:
As Reactant or Product:

  1. rMT-CO2@Mitochondrial Matrix map map MT-CO2@Mitochondrial inner membrane map

  2. MT-CO2@Mitochondrial inner membrane map + Cu2+@Mitochondrial inner membrane map map Cu2+:​MT-CO2@Mitochondrial inner membrane map
  3. COX4I1:​COX5A:​COX5B:​COX6A*:​COX6B*:​COX6C:​COX7A*:​COX7B*:​COX7C:​COX8*:​Cu2+:​MT-CO1:​MT-CO2:​MT-CO3:​heme a@Mitochondrial inner membrane map + COX4I2@Mitochondrial inner membrane map + ATP@Mitochondrial Matrix map map COX4I2:​COX5A:​COX5B:​COX6A*:​COX6B*:​COX6C:​COX7A*:​COX7B*:​COX7C:​COX8*:​Cu2+:​MT-CO1:​MT-CO2:​MT-CO3:​heme a@Mitochondrial inner membrane map + ADP@Mitochondrial Matrix map
  4. degraded + MT-CO1@Mitochondrial inner membrane map + COX5A@Mitochondrial inner membrane map + COX6A*@Mitochondrial inner membrane map + COX5B@Mitochondrial inner membrane map + COX7A*@Mitochondrial inner membrane map + heme a@Mitochondrial Matrix map + MT-CO3@Mitochondrial inner membrane map + Cu2+:​MT-CO2@Mitochondrial inner membrane map map COX4I1:​COX5A:​COX5B:​COX6A*:​COX6B*:​COX6C:​COX7A*:​COX7B*:​COX7C:​COX8*:​Cu2+:​MT-CO1:​MT-CO2:​MT-CO3:​heme a@Mitochondrial inner membrane map

As Catalyser:

  1. Cytochrome_C*|​ferroheme:​cardiolipin@Mitochondrial inner membrane map + H+@Mitochondrial Matrix map + O_sub_2_endsub_@Mitochondrial inner membrane map map Cytochrome_C*|​ferriheme:​cardiolipin@Mitochondrial inner membrane map + H+@Mitochondrial intermembrane space map

  2. Cytochrome_C*|​ferroheme:​cardiolipin@Mitochondrial inner membrane map + O_sub_2_endsub_@Mitochondrial intermembrane space map map Cytochrome_C*|​ferriheme:​cardiolipin@Mitochondrial inner membrane map + H_sub_2_endsub_O_sub_2_endsub_@Mitochondrial intermembrane space map

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