MSK*

Protein MSK* map

Identifiers
ribosomal protein S6 kinase 90kDa polypeptide 4
“ribosomal protein S6 kinase 90kD polypeptide 4″
HUGO:RPS6KA4 HGNC:10433 ENTREZ:8986 UNIPROT:O75676 GENECARDS:RPS6KA4 REACTOME:93591 KEGG:8986 ATLASONC:GC_RPS6KA4 WIKI:RPS6KA4
ribosomal protein S6 kinase 90kDa polypeptide 5
“ribosomal protein S6 kinase 90kD polypeptide 5″
HUGO:RPS6KA5 HGNC:10434 ENTREZ:9252 UNIPROT:O75582 GENECARDS:RPS6KA5 REACTOME:93593 KEGG:9252 ATLASONC:GC_RPS6KA5 WIKI:RPS6KA5

Maps_Modules
 Survival  map  / MAPK  map

References
MSK1 and MSK2 are potently activated (by phosphorylation) in vivo by ERK1/2 and P38 but not JNK. They are localised in the nucleus of quiescent and activated cells which suggest that they may preferentially phosphorylate nuclear substrates.
PMID:15187187

MSK*@Nucleus

References
s_mpk1_re95( Survival  map ):
MSK1 and MSK2 are potently activated (by phosphorylation) in vivo by ERK1/2 and P38 but not JNK. They are localised in the nucleus of quiescent and activated cells which suggest that they may preferentially phosphorylate nuclear substrates.
PMID:15187187

MSK*|​pho@Nucleus

References
s_mpk1_re95( Survival  map ):
MSK1 and MSK2 are potently activated (by phosphorylation) in vivo by ERK1/2 and P38 but not JNK. They are localised in the nucleus of quiescent and activated cells which suggest that they may preferentially phosphorylate nuclear substrates.
PMID:15187187
s_mpk1_re96( Survival  map ):
MSK1 rather than RSK1 mediates the mitogen-stimulated phoshphorylation of CREB.
s_mpk1_re260( Survival  map ):
Translocation of ERK into the nucleus activates the mitogen activated and stress-activated protein kinase 1 (MSK1) a histone H3 kinase that can relax chromatin thus making it more transcriptionally accessible. This alteration in the chromatin state induces MYC a gene that encodes the C-MYC protein a transcription factor that controls the cell cycle.
PMID:17158541
s_s_mpk1_re96( Survival  map ):


Modifications:
In compartment: Nucleus
  1. MSK*@Nucleus map

  2. MSK*|​pho@Nucleus map

Participates in complexes:

    Participates in reactions:
    As Reactant or Product:

    1. MSK*|​pho@Nucleus map map gMYC@Nucleus map

    2. MSK*@Nucleus map map MSK*|​pho@Nucleus map

    As Catalyser:

    1. CREB1@Nucleus map map CREB1|​pho@Nucleus map

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