MRE11*:NBS1*:RAD50

Complex MRE11*:NBS1*:RAD50 map


Complex composition:

  1. RAD50 map
  2. MRE11* map
  3. NBS1* map




MRE11*:​NBS1*:​RAD50@Nucleus

Identifiers
NAME:MRE11*:NBS1*:RAD50

References
a_re1477( Apoptosis  map ):
influenceDelete: re to reactants
PMID:18813293
review
through RAD50

Confidence
REF=0 FUNC=5

MRE11*:​NBS1*|​S343_pho:​RAD50@default

Identifiers
NAME:MRE11*:NBS1*:RAD50

Maps_Modules
 DNA repair  map  / S_PHASE_CHECKPOINT  map
 DNA repair  map  / G2_M_CHECKPOINT  map
 DNA repair  map  / HR  map
 DNA repair  map  / A_NHEJ  map

References
PMID:18809224, PMID:18584027, PMID:19772495, PMID:18087292
Double strand breaks sensor. MRN complex association is a first event after the DNA damage
PMID:16531125, PMID:17303408, PMID:16163361
For S-phase checkpoint
PMID:19793801, PMID:11850621
d_re91( DNA repair  map ):
MRN complex:
PMID:16531125, PMID:17303408
Double strand breaks sensor.
MRN complex association is a first event after the DNA damage.
d_re36( DNA repair  map ):
PMID:16332722
Auto-phosphorylation of ATM in response to DNA DSB:
PMID:17303408, PMID:12556884, PMID:16858402
Amplification of ATM auto-phosphorylation by the complex ATM:MRNcomplex:H2AX:MDC1CDK5 phosphorylates and activates ATM
PMID:19151707
d_re97:( DNA repair  map ) PMID:17303408, PMID:16163361, PMID:15964794
d_re105( DNA repair  map ):
PMID:18584027, PMID:17965729, PMID:20064462, PMID:18809224
For inhibition of A_NHEJ by DNA-PKs:
PMID:15211575
For stimulation of A_NHEJ by PARP1:
PMID:15498778, PMID:19362533, PMID:24050180
For role of MRN complex in A_NHEJ:
PMID:19654615, PMID:19892829
BLM inhibits A_NHEJ (alt_NHEJ):
PMID:24089143
PMID:24095737
d_re113:( DNA repair  map ) PMID:18171670
d_re115( DNA repair  map ):
PMID:16581787,
For inhibition of S-checkpoint by ATM:
PMID:15175241
Inhibition of Sphase by MRE complex:
PMID:17713585
By CycE*/CDK2: G1/S transition
By CycD*/CDK2/CIp/KIP: checkpoint G1/S
d_re156( DNA repair  map ):
MRN complex co-locolises at the FA foci and modulates propagation of ICL repair by Fanconi PMID:15136767, PMID:19622404
RPA is required for the replication fork block and remodeling toward DNA repair:
PMID:19622404
For role of SNM1B in Fanconi and S-phase checkpoint
PMID:18469862
d_re162( DNA repair  map ):
Link between HR, NER to Fanconi anemia pathway.
PMID:19686080
For ERCC1/XPF:
PMID:10882712, PMID:19805513
For MUS81/Eme1:
PMID:17036055:G
FANCA modulates XPF function:
MRN complex, FANCD2 and SNM1B are modulators of the DNA to release stalled fork:
PMD:19622404
d_re165( DNA repair  map ):
Link between Fanconi pathway and HR.
Fanconi pathway is a coordination of NER, TLS and HR
PMID:19686080:G
POLH activates D-loop extension. PoLN:HEL308* participate in HR and Fanconi. PolN:FANCD2:FANCI complex activate HR:
PMID:16337602
For role of SMARCAL1/RPA in stalled replication fork repair and in the homologous recombination:
PMID:19841479, PMID:19793861, PMID:19793862
d_re187( DNA repair  map ):
PMID:18931676, PMID:19686080
Link between cell cycle and activation of Fanconi pathway
NBS1 is required for FANCD2 phosphorylation and relocation into the FA core complex:
PMID:14988723
d_re206( DNA repair  map ):
Phosphorylation of NBS1 bt ATR in responce to crosslink-activation of S phase checkpoint
PMID:15136767
Formation of the complex for crosslink-activation of S phase checkpoint. FA core complex activates the reaction to stop cell cycle propagation:

Confidence
REF=5 FUNC=5


Modifications:
Participates in complexes:
In compartment: Nucleus
  1. MRE11*:​NBS1*:​RAD50@Nucleus map

In compartment: default

  1. MRE11*:​NBS1*|​S343_pho:​RAD50@default map

Participates in reactions:
As Reactant or Product:

  1. MRE11*:​NBS1*:​RAD50@Nucleus map map RAD50@Site of DNA damage map + MRE11*@Site of DNA damage map + NBS1*@Site of DNA damage map

  2. NBS1*@Nucleus map + MRE11*@Nucleus map + RAD50@Nucleus map map MRE11*:​NBS1*:​RAD50@Nucleus map
  3. BRCA1|​S988_pho|​S1387_pho|​S1423_pho|​S1497_pho|​S1524_pho:​CTIP*|​emp|​S372_pho|​T847_pho|​S267_pho|​BRCA1-dep_ubi@default map + MRE11*:​NBS1*|​S343_pho:​RAD50@default map + PARP1|​PolyADPribose_unk|​pho:​PARP2|​unk|​pho@default map map BRCA1:​CTIP*|​emp|​S372_pho|​T847_pho|​S267_pho|​BRCA1-dep_ubi:​MRE11*:​NBS1*|​S343_pho:​PARP1|​PolyADPribose_unk|​pho:​PARP2|​unk|​pho:​RAD50@default map
  4. FANCD2|​K561_ubi|​pho@default map + MRE11*:​NBS1*|​S343_pho:​RAD50@default map + ATR|​pho|​active@Nucleus map map ATR|​pho:​FANCD2|​K561_ubi|​pho:​MRE11*:​NBS1*|​S343_pho:​RAD50@default map
  5. MRE11*@default map + RAD50@default map + NBS1*|​S343_pho@default map map MRE11*:​NBS1*|​S343_pho:​RAD50@default map
  6. ATM|​pho|​S367_pho|​S1893_pho|​active@default map + MRE11*:​NBS1*|​S343_pho:​RAD50@default map map ATM|​pho|​S367_pho|​S1893_pho:​MRE11*:​NBS1*|​S343_pho:​RAD50@default map

As Catalyser:

  1. gA_NHEJ_DNA_st1*@Nucleus map map gA_NHEJ_DNA_st2*@Nucleus map

  2. G1 phase@default map map S phase@default map
  3. gFanconi_DNA_st2*@Nucleus map map gFanconi_DNA_st3*@Nucleus map
  4. gFanconi_DNA_st3*@Nucleus map map gFanconi_DNA_st4*@Nucleus map
  5. gFanconi_DNA_st4*@Nucleus map map gHR_DNA_st2*@Nucleus map
  6. FANCD2@default map map FANCD2|​pho@default map
  7. gSSA_DNA_st1*@Nucleus map map gSSA_DNA_st2*@Nucleus map
  8. ATM@default map map ATM|​pho|​S367_pho|​S1893_pho|​active@default map

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