MMP9

RNA MMP9 map

Identifiers
matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)
HUGO:MMP9 HGNC:7176 ENTREZ:4318 UNIPROT:P14780 GENECARDS:MMP9 REACTOME:59395 KEGG:4318 ATLASONC:MMP9ID41408ch20q11 WIKI:MMP9
CLG4B “matrix metalloproteinase 9 (gelatinase B 92kD gelatinase 92kD type IV collagenase)” “matrix metalloproteinase 9 (gelatinase B 92kDa gelatinase 92kDa type IV collagenase)”

Maps_Modules
 EMT  map  / EMT_REGULATORS  map
 EMT  map  / ECM  map
 Survival  map  / WNT_CANONICAL  map

rMMP9@Nucleus

Maps_Modules
 EMT  map  / EMT_REGULATORS  map
 EMT  map  / ECM  map

References
e_re65( EMT  map ):
PMID:10048576
The gene expressions of MMP-1, MMP-3, and MMP-9 and gelatinolytic activity of MMP-9 were significantly increased in high ETS-1 expression cells.
Low ETS-1 expression cells could not spread on a vitronectin substratum, and the phosphorylation of focal adhesion kinase was markedly impaired because of the reduced expression of integrin b3
PMID:16079281
MMP-9 transcription is activated in response to Snail expression
Oncogenic H-Ras (RasV12) synergistically co-operates with Snail in the induction of MMP-9 transcription and expression.
Phosphorylated Sp-1 is recruited to the MMP-9 promoter following activation of the Erk1/2 pathway
PMID:19564415
The transcription factor FOXO3, negatively regulated by binding to 14-3-3 protein family, induces MMP9 and MMP13 expression.
This explains the role of FOXO3 in promoting tumor invasion.


Modifications:
In compartment: Nucleus
  1. rMMP9@Nucleus map

Participates in complexes:

    Participates in reactions:
    As Reactant or Product:

    1. gMMP9@Nucleus map map rMMP9@Nucleus map

    2. rMMP9@Nucleus map map MMP9@Cytoplasm map
    3. gMMP9@Nucleus map map rMMP9@Nucleus map

    As Catalyser:

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