matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)
HUGO:MMP9 HGNC:7176 ENTREZ:4318 UNIPROT:P14780 GENECARDS:MMP9 REACTOME:59395 KEGG:4318 ATLASONC:MMP9ID41408ch20q11 WIKI:MMP9
CLG4B “matrix metalloproteinase 9 (gelatinase B 92kD gelatinase 92kD type IV collagenase)” “matrix metalloproteinase 9 (gelatinase B 92kDa gelatinase 92kDa type IV collagenase)”
e_re65( EMT ):
The gene expressions of MMP-1, MMP-3, and MMP-9 and gelatinolytic activity of MMP-9 were significantly increased in high ETS-1 expression cells.
Low ETS-1 expression cells could not spread on a vitronectin substratum, and the phosphorylation of focal adhesion kinase was markedly impaired because of the reduced expression of integrin b3
MMP-9 transcription is activated in response to Snail expression
Oncogenic H-Ras (RasV12) synergistically co-operates with Snail in the induction of MMP-9 transcription and expression.
Phosphorylated Sp-1 is recruited to the MMP-9 promoter following activation of the Erk1/2 pathway
The transcription factor FOXO3, negatively regulated by binding to 14-3-3 protein family, induces MMP9 and MMP13 expression.
This explains the role of FOXO3 in promoting tumor invasion.
In compartment: Nucleus
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