MMP13*

Protein MMP13* map

Identifiers
matrix metallopeptidase 13 (membrane-inserted)
HUGO:MMP13 HGNC:7159 ENTREZ:4322 UNIPROT:P45452 GENECARDS:MMP13 REACTOME:59403 KEGG:4322 ATLASONC:GC_MMP13 WIKI:MMP13

Maps_Modules
 EMT  map  / EMT_REGULATORS  map
 EMT  map  / ECM  map

References
PMID:21900405
MMP13 activates TGFB by cleavage of LAP

MMP13*@Extracellular space

References
e_re228( EMT  map ):
PMID:21900405
MMP13 activates TGFB by cleavage of LAP
Plasmin activates TGFB by cleavage of LAP
MMP9 activates TGFB by cleavage of LAP
Integrin aVb6 activates the ECM-bound latent TGFB1 and TGFB3 by traction
Integrin aVb8 and MMP14 (so-called MT1-MMP) cooperate to activate the ECM-bound latent TGFB1 and TGFB3:
-Integrin aVb8 binds LAP from the large latent complex
-MMP14 then is recruited to cleave LAP


Modifications:
In compartment: Extracellular space
  1. MMP13*@Extracellular space map

Participates in complexes:
In compartment: Extracellular space

  1. MMP13*:​TIMP family*@Extracellular space map

Participates in reactions:
As Reactant or Product:

  1. MMP13@Extracellular space map map MMP13*@Extracellular space map

  2. TIMP family*@Extracellular space map + MMP13*@Extracellular space map map MMP13*:​TIMP family*@Extracellular space map

As Catalyser:

  1. COL2A1@Extracellular space map map Collagen2*@Extracellular space map

  2. Collagen4*@Extracellular space map map Truncated Collagen4*@Extracellular space map
  3. LTBP1:​Latency-associated protein*|​hm2:​TGFB1|​hm2@Extracellular space map map TGFB1|​hm2|​active@Extracellular space map + LTBP1:​Latency-associated protein*|​hm2@Extracellular space map

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