MMP1

Gene MMP1 map

Identifiers
matrix metallopeptidase 1 (interstitial collagenase)
HUGO:MMP1 HGNC:7155 ENTREZ:4312 UNIPROT:P03956 GENECARDS:MMP1 REACTOME:59385 KEGG:4312 ATLASONC:GC_MMP1 WIKI:MMP1

Maps_Modules
 EMT  map  / EMT_REGULATORS  map
 EMT  map  / ECM  map

gMMP1@Nucleus

Maps_Modules
 EMT  map  / EMT_REGULATORS  map
 EMT  map  / ECM  map

References
PMID:22349261
e_re22( EMT  map ):
PMID:10048576
The gene expressions of MMP-1, MMP-3, and MMP-9 and gelatinolytic activity of MMP-9 were significantly increased in high ETS-1 expression cells.
Low ETS-1 expression cells could not spread on a vitronectin substratum, and the phosphorylation of focal adhesion kinase was markedly impaired because of the reduced expression of integrin b3
PMID:19208835
TCF8 (ZEB1) regulates cell invasion and migration via MMP1 expression.
TCF8 is likely to be dispensable for endothelial cell motility.
One possible mechanism underlying the increased invasiveness and migration might be the up-regulated digestion of ECMs via TCF8-mediated transcriptional regulation of the gene encoding MMP1.
MMP1 induction during tube formation was significantly enhanced in Matrigel when TCF8 was silenced
PMID:21081489
MiR-200b Regulates Ets-1-associated Genes
Suppression of endogenous miR-200b induced MMP-1 and VEGFR2 expressions
Overexpression of Ets-1 did not completely reverse miR- 200b-associated MMP-1 and VEGFR2 down-regulation.
It indicates that miR-200b, apart from targeting Ets-1, might silence other target proteins involved in transcription of the indicated genes.


Modifications:
In compartment: Nucleus
  1. gMMP1@Nucleus map

Participates in complexes:

    Participates in reactions:
    As Reactant or Product:

    1. gMMP1@Nucleus map map rMMP1@Nucleus map

    As Catalyser:

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