MLST8:MTOR:RPTOR

Complex MLST8:MTOR:RPTOR map


Complex composition:

  1. MTOR map
  2. MLST8 map
  3. RPTOR map




MLST8:​MTOR:​RPTOR@Cytoplasm

Identifiers
NAME:MLST8:MTOR:RPTOR

References
a_re369:( Apoptosis  map ) logical:re369_s2093=FALSE
a_re371( Apoptosis  map ):
influenceDelete: re to reactants
engagement of mTOR in mTORC1 does not titrate it out of mTORC2
a_re373( Apoptosis  map ):
PMID:19339977
review
proposed RSK mediated phosphorylation of RAPTOR might provide a mechanism to overcome the inhibitory effect of AKT1S1
a_re996:( Apoptosis  map ) reactionType:is.a

Confidence
REF=0 FUNC=5

MLST8:​MTOR:​RPTOR|​pho@Cytoplasm

Identifiers
NAME:MLST8:MTOR:RPTOR

References
a_re373( Apoptosis  map ):
PMID:19339977
review
proposed RSK mediated phosphorylation of RAPTOR might provide a mechanism to overcome the inhibitory effect of AKT1S1
a_re887:( Apoptosis  map ) reactionType:is.a

Confidence
REF=0 FUNC=5

MLST8:​MTOR:​RPTOR|​unk@Cytoplasm

Identifiers
NAME:MLST8:MTOR:RPTOR

References
a_re996:( Apoptosis  map ) reactionType:is.a
a_re374( Apoptosis  map ):
PMID:15854902
PMID:19299511
in vitro reconstituted system, FKBP8 is not required for TORC1 activation by RHEB
a_re998( Apoptosis  map ):
PMID:17991864
FKBP8 antagonizes mTORC1, and mediates RHEB induced mTORC1 activation

Confidence
REF=3 FUNC=5

MLST8:​MTOR:​RPTOR|​unk@PML Body

Identifiers
NAME:MLST8:MTOR:RPTOR

References
a_re888( Apoptosis  map ):
PMID:16915281
in mouse, PML directs mTOR to the nucleus, thereby inhibiting its interaction with Rheb and its ability to promote HIF1A translation

Confidence
REF=1 FUNC=5

MLST8:​MTOR:​RPTOR|​unk@Nucleus

Identifiers
NAME:MLST8:MTOR:RPTOR

References
a_re888( Apoptosis  map ):
PMID:16915281
in mouse, PML directs mTOR to the nucleus, thereby inhibiting its interaction with Rheb and its ability to promote HIF1A translation

Confidence
REF=1 FUNC=5


Modifications:
Participates in complexes:
In compartment: Cytoplasm
  1. MLST8:​MTOR:​RPTOR@Cytoplasm map

  2. MLST8:​MTOR:​RPTOR|​pho@Cytoplasm map
  3. MLST8:​MTOR:​RPTOR|​unk@Cytoplasm map

In compartment: Nucleus

  1. MLST8:​MTOR:​RPTOR|​unk@Nucleus map

In compartment: PML Body

  1. MLST8:​MTOR:​RPTOR|​unk@PML Body map

Participates in reactions:
As Reactant or Product:

  1. DEPDC6@Cytoplasm map + MLST8:​MTOR:​RPTOR|​unk@Cytoplasm map map DEPDC6:​MLST8:​MTOR:​RPTOR|​unk@Cytoplasm map

  2. MLST8:​MTOR:​RPTOR@Cytoplasm map + PRAS40*@Cytoplasm map map MLST8:​MTOR:​PRAS40*:​RPTOR@Cytoplasm map
  3. 14-3-3*|​unk@Cytoplasm map + MLST8:​MTOR:​PRAS40*|​pho:​RPTOR@Cytoplasm map map MLST8:​MTOR:​RPTOR@Cytoplasm map + 14-3-3*|​unk:​PRAS40*|​pho@Cytoplasm map
  4. MLST8@Cytoplasm map + MTOR@Cytoplasm map + RPTOR@Cytoplasm map map MLST8:​MTOR:​RPTOR@Cytoplasm map
  5. MLST8:​MTOR:​RPTOR@Cytoplasm map map MLST8:​MTOR:​RPTOR|​pho@Cytoplasm map
  6. MLST8:​MTOR:​RPTOR|​unk@Cytoplasm map map MLST8:​MTOR:​RPTOR|​unk@Cytoplasm map
  7. MLST8:​MTOR:​RPTOR|​unk@Cytoplasm map map MLST8:​MTOR:​RPTOR|​unk@Nucleus map
  8. MLST8:​MTOR:​RPTOR|​unk@Cytoplasm map map MLST8:​MTOR:​RPTOR|​pho@Cytoplasm map
  9. MLST8:​MTOR:​RPTOR|​unk@Nucleus map map MLST8:​MTOR:​RPTOR|​unk@PML Body map
  10. YY1@Nucleus map + PPARGC1A@Nucleus map + MLST8:​MTOR:​RPTOR|​unk@Nucleus map map MLST8:​MTOR:​PPARGC1A:​RPTOR|​pho:​YY1@Nucleus map
  11. MLST8:​MTOR:​RPTOR@Cytoplasm map map MLST8:​MTOR:​RPTOR|​unk@Cytoplasm map
  12. MLST8:​MTOR:​RPTOR|​pho@Cytoplasm map map MLST8:​MTOR:​RPTOR|​unk@Cytoplasm map
  13. MLST8:​MTOR:​RPTOR|​unk@Cytoplasm map + FKBP8@Cytoplasm map map FKBP8:​MLST8:​MTOR:​RPTOR|​unk@Cytoplasm map

As Catalyser:

  1. DEPDC6@Cytoplasm map map DEPDC6|​pho@Cytoplasm map

  2. rHIF1A@Nucleus map map HIF1A@Cytoplasm map
  3. MLST8:​MTOR:​PRAS40*:​RPTOR@Cytoplasm map map MLST8:​MTOR:​PRAS40*|​pho:​RPTOR@Cytoplasm map
  4. degraded map Autophagy@Cytoplasm map
  5. S6K*@Cytoplasm map map S6K*|​pho@Cytoplasm map
  6. 4E-BP*@Cytoplasm map map 4E-BP*|​pho@Cytoplasm map

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