MLH1:PMS2

Complex MLH1:PMS2 map


Complex composition:

  1. MLH1 map
  2. PMS2 map




MLH1:​PMS2@default

Identifiers
NAME:MLH1:PMS2

Maps_Modules
 DNA repair  map  / MMR  map
 DNA repair  map  / BER  map

References
d_re36( DNA repair  map ):
PMID:16332722
Auto-phosphorylation of ATM in response to DNA DSB:
PMID:17303408, PMID:12556884, PMID:16858402
Amplification of ATM auto-phosphorylation by the complex ATM:MRNcomplex:H2AX:MDC1CDK5 phosphorylates and activates ATM
PMID:19151707
d_re37( DNA repair  map ):
PMID:16332722, PMID:15136767
ATR binds stalled fork and phosphorylates CHK1 that activates checkpoint, stops cell cycle
d_re250( DNA repair  map ):
Link between MMR and Fanconi:
PMID:17581638
d_re260( DNA repair  map ):
DNA with O6-methylguanine adducts, MutSalpha and MutLalpha activate ATR/ATRIP and BER pathways performs the repair:
PMID:16713580, PMID:18543256
Damaged DNA triggers ATR/ATRIP complex activation
d_re438:( DNA repair  map ) reactionType:is.a

Confidence
REF=5 FUNC=5


Modifications:
Participates in complexes:
In compartment: default
  1. MLH1:​PMS2@default map

Participates in reactions:
As Reactant or Product:

  1. MLH1:​PMS2@default map + ERCC1:​XPF*@default map map ERCC1:​MLH1:​PMS2:​XPF*@default map

  2. FANCJ*@default map + MLH1:​PMS2@default map map FANCJ*:​MLH1:​PMS2@default map
  3. MLH1@default map + PMS2@default map map MLH1:​PMS2@default map
  4. MLH1:​PMS2@default map map d_s834

As Catalyser:

  1. ATR|​pho|​active@Nucleus map + ATRIP@default map map ATRIP:​ATR|​pho@default map

  2. ATM@default map map ATM|​pho|​S367_pho|​S1893_pho|​active@default map
  3. ATR@default map map ATR|​pho|​active@Nucleus map

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