MKNK2

Protein MKNK2 map

Identifiers
MAP kinase interacting serine/threonine kinase 2
HUGO:MKNK2 HGNC:7111 ENTREZ:2872 UNIPROT:Q9HBH9 GENECARDS:MKNK2 KEGG:2872 ATLASONC:GC_MKNK2 WIKI:MKNK2

Maps_Modules
 EMT  map  / EMT_REGULATORS  map

References
PMID:9155017
Mnk1 and Mnk2 bind to Erk1, Erk2 and p38 but not JNK
Mnk1 and Mnk2 are in vitro substrates of Erk2 and p38
Mnk1 is a MAP kinase-activated eIF-4E kinase

MKNK2@Cytoplasm

References
e_re397( EMT  map ):
PMID:9604935
Phosphorylation of ERK-1/2 promotes its homodimerization
PMID:18775330
Scaffolds and ERK dimers are essential for the activation of cytoplasmic but not nuclear substrates.
Dimerization is critical for connecting the scaffolded ERK complex to cognate cytoplasmic substrates.
Contrarily, nuclear substrates associate to ERK monomers.
PMID:9155017
Mnk1 and Mnk2 bind to Erk1, Erk2 and p38 but not JNK
Mnk1 and Mnk2 are in vitro substrates of Erk2 and p38
Mnk1 is a MAP kinase-activated eIF-4E kinase

MKNK2|​pho@Cytoplasm

References
e_re397( EMT  map ):
PMID:9604935
Phosphorylation of ERK-1/2 promotes its homodimerization
PMID:18775330
Scaffolds and ERK dimers are essential for the activation of cytoplasmic but not nuclear substrates.
Dimerization is critical for connecting the scaffolded ERK complex to cognate cytoplasmic substrates.
Contrarily, nuclear substrates associate to ERK monomers.
PMID:9155017
Mnk1 and Mnk2 bind to Erk1, Erk2 and p38 but not JNK
Mnk1 and Mnk2 are in vitro substrates of Erk2 and p38
Mnk1 is a MAP kinase-activated eIF-4E kinase


Modifications:
In compartment: Cytoplasm
  1. MKNK2@Cytoplasm map

  2. MKNK2|​pho@Cytoplasm map

Participates in complexes:

    Participates in reactions:
    As Reactant or Product:

    1. MKNK2@Cytoplasm map + ATP@Cytoplasm map map MKNK2|​pho@Cytoplasm map + ADP@Cytoplasm map

    As Catalyser:

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