MKNK1

Protein MKNK1 map

Identifiers
MAP kinase interacting serine/threonine kinase 1
HUGO:MKNK1 HGNC:7110 ENTREZ:8569 UNIPROT:Q9BUB5 GENECARDS:MKNK1 REACTOME:95412 KEGG:8569 ATLASONC:GC_MKNK1 WIKI:MKNK1

Maps_Modules
 EMT  map  / EMT_REGULATORS  map

References
PMID:9155017
Mnk1 and Mnk2 bind to Erk1, Erk2 and p38 but not JNK
Mnk1 and Mnk2 are in vitro substrates of Erk2 and p38
Mnk1 is a MAP kinase-activated eIF-4E kinase. In vitro, Mnk1 rapidly phosphorylates eIF-4E at the physiologically relevant site, Ser209
PMID:9878069
Human eukaryotic translation initiation factor 4G (eIF4G) recruits mnk1 to phosphorylate eIF4E.
Phosphorylation of eIF-4E is believed to enhance its affinity for the 5′-cap

MKNK1@Cytoplasm

References
e_re396( EMT  map ):
PMID:9604935
Phosphorylation of ERK-1/2 promotes its homodimerization
PMID:18775330
Scaffolds and ERK dimers are essential for the activation of cytoplasmic but not nuclear substrates.
Dimerization is critical for connecting the scaffolded ERK complex to cognate cytoplasmic substrates.
Contrarily, nuclear substrates associate to ERK monomers.
PMID:9155017
Mnk1 and Mnk2 bind to Erk1, Erk2 and p38 but not JNK
Mnk1 and Mnk2 are in vitro substrates of Erk2 and p38
Mnk1 is a MAP kinase-activated eIF-4E kinase

MKNK1|​pho@Cytoplasm

References
e_re396( EMT  map ):
PMID:9604935
Phosphorylation of ERK-1/2 promotes its homodimerization
PMID:18775330
Scaffolds and ERK dimers are essential for the activation of cytoplasmic but not nuclear substrates.
Dimerization is critical for connecting the scaffolded ERK complex to cognate cytoplasmic substrates.
Contrarily, nuclear substrates associate to ERK monomers.
PMID:9155017
Mnk1 and Mnk2 bind to Erk1, Erk2 and p38 but not JNK
Mnk1 and Mnk2 are in vitro substrates of Erk2 and p38
Mnk1 is a MAP kinase-activated eIF-4E kinase
e_re398( EMT  map ):
PMID:9878069
Human eukaryotic translation initiation factor 4G (eIF4G) recruits mnk1 to phosphorylate eIF4E.
In vitro, Mnk1 rapidly phosphorylates eIF-4E at the physiologically relevant site, Ser209


Modifications:
In compartment: Cytoplasm
  1. MKNK1@Cytoplasm map

  2. MKNK1|​pho@Cytoplasm map

Participates in complexes:

    Participates in reactions:
    As Reactant or Product:

    1. MKNK1@Cytoplasm map + ATP@Cytoplasm map map MKNK1|​pho@Cytoplasm map + ADP@Cytoplasm map

    As Catalyser:

    1. EIF4E@Cytoplasm map map EIF4E|​pho@Cytoplasm map

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