MIR17-92*

Antisense RNA MIR17-92* map

Identifiers
miR-17-92 cluster host gene (non-protein coding)
HUGO:MIR17HG HGNC:23564 ENTREZ:407975 UNIPROT:Q75NE6 GENECARDS:MIR17HG KEGG:407975 ATLASONC:GC_MIR17HG WIKI:MIR17HG

Maps_Modules
 Apoptosis  map  / APOPTOSIS_GENES  map

arMIR17-92*@Nucleus

References
a_re146( Apoptosis  map ):
PMID:18328430
MIR17HG transactivation by E2F1
PMID:15944709
MIR17-92 cluster transactivation by MYC
PMID:19696742
MIR17HG transactivation repressed by TP53. Proposed mechanism: TP53- and TBP- binding sites overlaps.
in human colorectal carcinoma HCT116 (TP53 competent cells), MIR17HG repression upon hypoxia and TP53 stabilization.
in human colorectal carcinoma cells HCT116 and LOVO, this effect is blocked by siRNA against TP53
in HCT116 and LOVO, siRNA against MYC represses MIR17-92 expression
a_re147:( Apoptosis  map ) PMID:15136036


Modifications:
In compartment: Nucleus
  1. arMIR17-92*@Nucleus map

Participates in complexes:

    Participates in reactions:
    As Reactant or Product:

    1. gMIR17-92*@Nucleus map map arMIR17-92*@Nucleus map

    2. arMIR17-92*@Nucleus map map arMIR17@Cytoplasm map + arMIR18A@Cytoplasm map + arMIR19A@Cytoplasm map + arMIR20A@Cytoplasm map + arMIR19B1@Cytoplasm map + arMIR92A1@Cytoplasm map

    As Catalyser:

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