Membrane spreading

Phenotype Membrane spreading map
Membrane spreading@Cytoplasm

Maps_Modules
 EMT  map  / EMT_REGULATORS  map
 EMT  map  / CYTOSKELETON_POLARITY  map
 EMT  map  / CELL_CELL_ADHESIONS  map
 EMT  map  / CELL_MATRIX_ADHESIONS  map
 EMT  map  / ECM  map
 EMT  map  / TIGHT_JUNCTIONS  map
 EMT  map  / GAP_JUNCTIONS  map
 EMT  map  / ADHERENS_JUNCTIONS  map
 EMT  map  / DESMOSOMES  map

References
e_re983( EMT  map ):
PMID:9808620
Crk–p130Cas complexes regulate cell spreading after integrin stimulation and serve as amolecular switch for induction of cell migration
DOCK1 is suggested to be the downstream effector of Crk in integrin signaling:
-DOCK1 binds to Crk after integrin stimulation;
-DOCK1 colocalizes with the Crk2–p130Cas complexes at focal adhesions and at the sites of membrane spreading;
-Expression of DOCK1 accelerates the formation of the Crk–p130Cas complexes.
It is likely that the DOCK1 recruited to the Crk–p130Cas complexes on integrin stimulation transduces signals to Rac1 at focal adhesions, which eventually induces cell spreading.


Modifications:
In compartment: Cytoplasm
  1. Membrane spreading@Cytoplasm map

Participates in complexes:

    Participates in reactions:
    As Reactant or Product:

    1. CRK:​DOCK1:​PXN|​pho@Cytoplasm map map Membrane spreading@Cytoplasm map

    2. Membrane spreading@Cytoplasm map map Cell migration@Cytoplasm map
    3. GTP:​RAC1@Cytoplasm map map Membrane spreading@Cytoplasm map

    As Catalyser:

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