MEK2*

Protein MEK2* map

Identifiers
mitogen-activated protein kinase kinase 2
HUGO:MAP2K2 HGNC:6842 ENTREZ:5605 UNIPROT:P36507 GENECARDS:MAP2K2 REACTOME:59505 KEGG:5605 ATLASONC:GC_MAP2K2 WIKI:MAP2K2

Maps_Modules
 EMT  map  / EMT_REGULATORS  map

References
PMID:7565670
MEK-1/2 have a proline rich domain and critical Serine residues (MEK-1 S218/222, MEK-2 unknown, S) upon which the molecules may be phosphorylated.
MEK1/2 are found in the cytoplasm of unstimulated cells.
MEK-1/2 bind to active Raf-1 via the proline-rich domain.
Active Raf-1 is able to phosphorylate target Serine and Threonine residues in the presence of ATP
Active Raf-1 phosphorylates MEK-1/2 on Serine residues, converting ATP to ADP. The MEK-1/2 kinase is now active.

MEK2*@Cytoplasm

References
e_re389( EMT  map ):
PMID:7565670
Active Raf-1 phosphorylates MEK-1/2 on Serine residues, converting ATP to ADP. The MEK-1/2 kinase is now active.

MEK2*|​S_pho|​active@Cytoplasm

References
e_re389( EMT  map ):
PMID:7565670
Active Raf-1 phosphorylates MEK-1/2 on Serine residues, converting ATP to ADP. The MEK-1/2 kinase is now active.
e_re391( EMT  map ):
PMID:8388392
PMID:8226933
In the cytoplasm activated MEK1 (Serine phosphorylated) may encounter monomeric, inactive ERK1.
ERK1 in its inactive form is not phosphorylated on a critical Threonine (T) and a critical Tyrosine (Y).
MEK1 phosphorylates the critical Tyr and Thr on ERK1, converting two ATP to ADP. Phosphorylation of ERK-1 activates its kinase activity.


Modifications:
In compartment: Cytoplasm
  1. MEK2*@Cytoplasm map

  2. MEK2*|​S_pho|​active@Cytoplasm map

Participates in complexes:

    Participates in reactions:
    As Reactant or Product:

    1. MEK2*@Cytoplasm map + ATP@Cytoplasm map map MEK2*|​S_pho|​active@Cytoplasm map + ADP@Cytoplasm map

    As Catalyser:

    1. ERK2*@Cytoplasm map map ERK2*|​T_pho|​Y_pho|​active@Cytoplasm map

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