MEK1*

Protein MEK1* map

Identifiers
mitogen-activated protein kinase kinase 1
HUGO:MAP2K1 HGNC:6840 ENTREZ:5604 UNIPROT:Q02750 GENECARDS:MAP2K1 REACTOME:59503 KEGG:5604 ATLASONC:GC_MAP2K1 WIKI:MAP2K1
PRKMK1

Maps_Modules
 EMT  map  / EMT_REGULATORS  map
 Survival  map  / WNT_NON_CANONICAL  map

References
PMID:7565670
MEK-1/2 have a proline rich domain and critical Serine residues (MEK-1 S218/222, MEK-2 unknown, S) upon which the molecules may be phosphorylated.
MEK1/2 are found in the cytoplasm of unstimulated cells.
MEK-1/2 bind to active Raf-1 via the proline-rich domain.
Active Raf-1 is able to phosphorylate target Serine and Threonine residues in the presence of ATP
Active Raf-1 phosphorylates MEK-1/2 on Serine residues, converting ATP to ADP. The MEK-1/2 kinase is now active.
PMID:7731720
B-Raf protein isoforms interact with and phosphorylate Mek-1 on serine residues 218 and 222.

MEK1*@Cytoplasm

References
e_re388( EMT  map ):
PMID:7565670
Active Raf-1 phosphorylates MEK-1/2 on Serine residues, converting ATP to ADP. The MEK-1/2 kinase is now active.

MEK1*|​S218_pho|​S222_pho|​active@Cytoplasm

References
e_re388( EMT  map ):
PMID:7565670
Active Raf-1 phosphorylates MEK-1/2 on Serine residues, converting ATP to ADP. The MEK-1/2 kinase is now active.
e_re390( EMT  map ):
PMID:8388392
PMID:8226933
In the cytoplasm activated MEK1 (Serine phosphorylated) may encounter monomeric, inactive ERK1.
ERK1 in its inactive form is not phosphorylated on a critical Threonine (T) and a critical Tyrosine (Y).
MEK1 phosphorylates the critical Tyr and Thr on ERK1, converting two ATP to ADP. Phosphorylation of ERK-1 activates its kinase activity.

MEK1*@Nucleus

References
s_wnc3_re31( Survival  map ):
Phosphorylation of NFAT leads to increased DNA binding of NFAT -> increased gene transcription
PMID15657416
Not sure if dissociation of calcineurin and ERK/MEK occurs


Modifications:
In compartment: Cytoplasm
  1. MEK1*@Cytoplasm map

  2. MEK1*|​S218_pho|​S222_pho|​active@Cytoplasm map

In compartment: Nucleus

  1. MEK1*@Nucleus map

Participates in complexes:
In compartment: Nucleus

  1. CNA*:​CNB*:​ERK2*:​MEK1*:​NFAT*@Nucleus map

  2. CNA*:​CNB*:​ERK2*:​MEK1*:​NFAT*|​pho@Nucleus map

Participates in reactions:
As Reactant or Product:

  1. MEK1*@Cytoplasm map + ATP@Cytoplasm map map MEK1*|​S218_pho|​S222_pho|​active@Cytoplasm map + ADP@Cytoplasm map

  2. CNA*:​CNB*:​NFAT*@Nucleus map + ERK2*@Nucleus map + MEK1*@Nucleus map map CNA*:​CNB*:​ERK2*:​MEK1*:​NFAT*@Nucleus map
  3. CNA*:​CNB*:​ERK2*:​MEK1*:​NFAT*@Nucleus map map CNA*:​CNB*:​ERK2*:​MEK1*:​NFAT*|​pho@Nucleus map
  4. CNA*:​CNB*:​ERK2*:​MEK1*:​NFAT*|​pho@Nucleus map + gAP-1_ARRE binding sites*@Nucleus map + JUN@Nucleus map + FOS@Nucleus map map AP-1_ARRE binding sites*:​FOS:​JUN:​NFAT*@Nucleus map + CNA*:​CNB*@Nucleus map + ERK2*@Nucleus map + MEK1*@Nucleus map
  5. MAPK pathway@Cytoplasm map map MEK1*@Nucleus map

As Catalyser:

  1. ERK1*@Cytoplasm map map ERK1*|​T_pho|​Y_pho|​active@Cytoplasm map

  2. CNA*:​CNB*:​ERK2*:​MEK1*:​NFAT*|​pho@Nucleus map + gAP-1_ARRE binding sites*@Nucleus map + JUN@Nucleus map + FOS@Nucleus map map AP-1_ARRE binding sites*:​FOS:​JUN:​NFAT*@Nucleus map + CNA*:​CNB*@Nucleus map + ERK2*@Nucleus map + MEK1*@Nucleus map

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