MDM2:p53*

Complex MDM2:p53* map


Complex composition:

  1. p53* map
  2. MDM2 map




MDM2|​S186_pho:​p53*@Nucleus

Identifiers
NAME:MDM2:p53*

Maps_Modules
 EMT  map  / EMT_REGULATORS  map

References
PMID:15140942
Phosphorylations on p53 prevent its binding to MDM2.
PMID:15574337
S186 phosphorylation of MDM2 by AKT favors the binding of MDM2 to p53 and its following degradation.
e_re1213( EMT  map ):
PMID:19336515
TWIST1 physically promotes interaction between p53 and MDM2
e_re1214( EMT  map ):
PMID:9819415
Nuclear exports is required for degradation of p53 by MDM2
e_re1216( EMT  map ):
PMID:19448627
Complex of p53, MDM2 and Slug faciliates the proteasomal degradation of Slug by MDM2.

Confidence
REF=5 FUNC=5

MDM2|​S186_pho:​p53*@Cytoplasm

Identifiers
NAME:MDM2:p53*

Maps_Modules
 EMT  map  / EMT_REGULATORS  map

References
PMID:15140942
Phosphorylations on p53 prevent its binding to MDM2.
PMID:15574337
S186 phosphorylation of MDM2 by AKT favors the binding of MDM2 to p53 and its following degradation.
e_re1214( EMT  map ):
PMID:9819415
Nuclear exports is required for degradation of p53 by MDM2

Confidence
REF=3 FUNC=5


Modifications:
Participates in complexes:
In compartment: Cytoplasm
  1. MDM2|​S186_pho:​p53*@Cytoplasm map

In compartment: Nucleus

  1. MDM2|​S186_pho:​p53*@Nucleus map

Participates in reactions:
As Reactant or Product:

  1. p53*@Nucleus map + MDM2|​S186_pho@Nucleus map map MDM2|​S186_pho:​p53*@Nucleus map

  2. MDM2|​S186_pho:​p53*@Nucleus map map MDM2|​S186_pho:​p53*@Cytoplasm map
  3. MDM2|​S186_pho:​p53*@Cytoplasm map map degraded
  4. SNAI2@Nucleus map + MDM2|​S186_pho:​p53*@Nucleus map map MDM2|​S186_pho:​SNAI2:​p53*@Nucleus map
  5. MDM2|​S186_pho:​p53*@Nucleus map map degraded

As Catalyser:

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