MDM2

Gene MDM2 map

Identifiers
Mdm2 p53 binding protein homolog (mouse)
HUGO:MDM2 HGNC:6973 ENTREZ:4193 UNIPROT:Q00987 GENECARDS:MDM2 REACTOME:95018 KEGG:4193 ATLASONC:MDM2ID115ch12q15 WIKI:MDM2
MDM2 oncogene E3 ubiquitin protein ligase
“Mdm2 P53 binding protein homolog (mouse)” “Mdm2 P53 E3 ubiquitin protein ligase homolog (mouse)” “Mdm2 transformed 3T3 cell double minute 2 P53 binding protein (mouse)” “mouse double minute 2 human homolog of; P53-binding protein”

Maps_Modules
 EMT  map  / EMT_REGULATORS  map
 Survival  map  / MAPK  map
 Survival  map  / PI3K_AKT_MTOR  map

References
MDM2 = ubiquitin-ligase, regulates p53 stability: induce its degradation via the proteasome.
PMID:15024084
PMID:20679392
PMID:15169778
PMID:11923280
PMID:11715018
PMID:20673124

gMDM2@Nucleus

References
e_re1293( EMT  map ):
PMID:17550342
SNAI2 represses MDM2 expression, thus skip p53 from proteasomal degradation


Modifications:
In compartment: Nucleus
  1. gMDM2@Nucleus map

Participates in complexes:

    Participates in reactions:
    As Reactant or Product:

    1. gMDM2@Nucleus map map rMDM2@Nucleus map

    2. gMDM2@Nucleus map map rMDM2@Nucleus map
    3. p53*|​pho@Nucleus map map gMDM2@Nucleus map
    4. gMDM2@Nucleus map map c_s731

    As Catalyser:

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