MDM2

Protein MDM2 map

Identifiers
Mdm2 p53 binding protein homolog (mouse)
HUGO:MDM2 HGNC:6973 ENTREZ:4193 UNIPROT:Q00987 GENECARDS:MDM2 REACTOME:95018 KEGG:4193 ATLASONC:MDM2ID115ch12q15 WIKI:MDM2
MDM2 oncogene, E3 ubiquitin protein ligase
“Mdm2 P53 binding protein homolog (mouse)” “Mdm2 P53 E3 ubiquitin protein ligase homolog (mouse)” “Mdm2 transformed 3T3 cell double minute 2 P53 binding protein (mouse)” “mouse double minute 2 human homolog of; P53-binding protein”
Mdm2 p53 binding protein homo

Maps_Modules
 EMT  map  / EMT_REGULATORS  map
 Apoptosis  map  / APOPTOSIS_GENES  map
 DNA repair  map  / G2_M_CHECKPOINT  map
 Cell cycle  map  / CYCLINB  map
 Cell cycle  map  / APOPTOSIS_ENTRY  map
 Survival  map  / MAPK  map
 Survival  map  / PI3K_AKT_MTOR  map
 Survival  map  / WNT_NON_CANONICAL  map

References
MDM2 = ubiquitin-ligase, regulates p53 stability: induce its degradation via the proteasome.
PMID:15024084
PMID:14761977, PMID:11779693, PMID:17110379, PMID:9450543, PMID:15876864
The Mdm2 protein is involved in an autoregulatory feedback loop with P53 thus controlling its activity.
PMID:17158541
PMID:20679392
PMID:15169778
PMID:11923280
PMID:11715018

MDM2|​S395_pho@Nucleus

References
e_re1210( EMT  map ):
MDM2 phosphorylation by ATM inhibits its interaction with p53
PMID:15140942
Phosphorylation at Ser395
PMID:11331603

MDM2|​S186_pho@Nucleus

References
e_re1213( EMT  map ):
PMID:15140942
Phosphorylations on p53 prevent its binding to MDM2.
PMID:15574337
S186 phosphorylation of MDM2 by AKT favors the binding of MDM2 to p53 and its following degradation.
PMID:19336515
TWIST1 physically promotes interaction between p53 and MDM2

MDM2@Nucleus

References
e_re1210( EMT  map ):
MDM2 phosphorylation by ATM inhibits its interaction with p53
PMID:15140942
Phosphorylation at Ser395
PMID:11331603

MDM2|​pho@default

References
d_re49:( DNA repair  map ) PMID:19788416

MDM2@default

References
d_re48( DNA repair  map ):
BRCA1 stabilises p53 and causes activation of p53-dependent DNA-repair genes and activation of checkpoint, but no apoptoss:
PMID:12024039 , PMID:12496474
d_re49:( DNA repair  map ) PMID:19788416
d_re554:( DNA repair  map ) PMID:21727086, PMID:21922195, PMID:20724832

MDM2@Cytoplasm

References
c_re281( Cell cycle  map ):
MDM2 = ubiquitin-ligase, regulates p53 stability: induice its degradation via the proteasome.
PMID:15024084
c_re623:( Cell cycle  map ) PMID:9819415

MDM2|​S166_pho|​pho@Cytoplasm

References
s_akt1_re118( Survival  map ):
PMID:15169778
PMID:11923280
PMID:11715018
PMID:16697215

MDM2|​S166_emp@Cytoplasm

References
s_akt1_re118( Survival  map ):
PMID:15169778
PMID:11923280
PMID:11715018
PMID:16697215

MDM2|​S166_pho|​pho@Nucleus

References
s_akt1_re120( Survival  map ):
PMID:15169778
PMID:11923280
PMID:11715018

MDM2|​S166_pho|​pho|​S188_pho@Nucleus

References
s_akt1_re119( Survival  map ):
PMID:15169778
PMID:11923280
PMID:11715018

MDM2|​pho|​pho@Nucleus

References
s_akt2_re66:( Survival  map ) PMID15169778
s_akt2_re68:( Survival  map ) PMID:15169778 PMID:10722742

MDM2|​pho|​pho|​pho@Nucleus

References
s_akt2_re66:( Survival  map ) PMID15169778
s_akt2_re68:( Survival  map ) PMID:15169778 PMID:10722742
s_akt2_re70( Survival  map ):
PMID:10721693
PMID:19459846

MDM2|​pho|​pho|​ubi@Nucleus

References
s_akt2_re68:( Survival  map ) PMID:15169778 PMID:10722742


Modifications:
In compartment: Cytoplasm
  1. MDM2@Cytoplasm map

  2. MDM2|​S166_emp@Cytoplasm map
  3. MDM2|​S166_pho|​pho@Cytoplasm map

In compartment: Nucleus

  1. MDM2@Nucleus map

  2. MDM2|​S186_pho@Nucleus map
  3. MDM2|​S395_pho@Nucleus map
  4. MDM2|​pho|​pho@Nucleus map
  5. MDM2|​S166_pho|​pho@Nucleus map
  6. MDM2|​pho|​pho|​pho@Nucleus map
  7. MDM2|​pho|​pho|​ubi@Nucleus map
  8. MDM2|​S166_pho|​pho|​S188_pho@Nucleus map

In compartment: default

  1. MDM2@default map

  2. MDM2|​pho@default map

Participates in complexes:
In compartment: Cytoplasm

  1. MDM2|​S186_pho:​p53*@Cytoplasm map

In compartment: Nucleolus

  1. MDM2:​p14ARF*@Nucleolus map

In compartment: Nucleus

  1. MDM2|​S186_pho:​p53*@Nucleus map

  2. MDM2|​S186_pho:​SNAI2:​p53*@Nucleus map

Participates in reactions:
As Reactant or Product:

  1. MDM2@Nucleus map + p53*@Nucleus map map c_s731

  2. MDM2@Nucleus map map MDM2|​S395_pho@Nucleus map
  3. MDM2@Nucleus map + a_s3238 map c_s732
  4. c_s732 map MDM2:​p14ARF*@Nucleolus map
  5. c_s1127 map p53*@Cytoplasm map + MDM2@Cytoplasm map
  6. MDM2@Cytoplasm map map MDM2@Nucleus map
  7. MDM2@default map map MDM2|​pho@default map
  8. MDM2|​pho@default map map degraded
  9. MDM2@Nucleus map map MDM2|​S395_pho@Nucleus map
  10. MDM2@Nucleus map map MDM2|​S186_pho@Nucleus map
  11. p53*@Nucleus map + MDM2|​S186_pho@Nucleus map map MDM2|​S186_pho:​p53*@Nucleus map
  12. MDM2|​S186_pho:​p53*@Nucleus map map MDM2|​S186_pho:​p53*@Cytoplasm map
  13. MDM2|​S186_pho:​p53*@Cytoplasm map map degraded
  14. SNAI2@Nucleus map + MDM2|​S186_pho:​p53*@Nucleus map map MDM2|​S186_pho:​SNAI2:​p53*@Nucleus map
  15. MDM2|​S186_pho:​SNAI2:​p53*@Nucleus map map degraded
  16. rMDM2@Nucleus map map MDM2@Nucleus map
  17. MDM2|​S186_pho:​p53*@Nucleus map map degraded
  18. MDM2|​S166_emp@Cytoplasm map map MDM2|​S166_pho|​pho@Cytoplasm map
  19. MDM2|​S166_pho|​pho@Nucleus map map MDM2|​S166_pho|​pho|​S188_pho@Nucleus map
  20. MDM2|​S166_pho|​pho@Cytoplasm map map MDM2|​S166_pho|​pho@Nucleus map
  21. MDM2|​pho|​pho@Nucleus map map MDM2|​pho|​pho|​pho@Nucleus map
  22. MDM2|​pho|​pho@Nucleus map map MDM2|​pho|​pho|​ubi@Nucleus map

As Catalyser:

  1. p53*|​S15_pho|​active@Nucleus map map p53*@Nucleus map

  2. p53*@default map map degraded
  3. APE*@default map map APE*|​Thr233_pho|​ubi@default map
  4. MDM2|​pho|​pho@Nucleus map map MDM2|​pho|​pho|​ubi@Nucleus map
  5. p53*@Nucleus map map p53*|​ubi@Nucleus map
  6. p53*@Nucleus map map p53*|​ubi|​ubi@Nucleus map

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