MDC1

Protein MDC1 map

Identifiers
mediator of DNA-damage checkpoint 1
HUGO:MDC1 HGNC:21163 ENTREZ:9656 UNIPROT:Q14676 GENECARDS:MDC1 REACTOME:110541 KEGG:9656 ATLASONC:GC_MDC1 WIKI:MDC1

Maps_Modules
 Apoptosis  map  / MITOCH_METABOLISM  map
 DNA repair  map  / S_PHASE_CHECKPOINT  map
 DNA repair  map  / G2_M_CHECKPOINT  map
 DNA repair  map  / C_NHEJ  map
 DNA repair  map  / HR  map

References
PMID:18006705, PMID:17303408, PMID:18583988, PMID:18590585, PMID:17660363, PMID:7575488, PMID:15279786
For S-phase checkpoint
PMID:15459660, PMID:12607003, PMID:18583988, PMID:9407949, PMID:18678890

MDC1|​T752_pho|​T699_pho|​T719_pho|​Nter-SDT-motifs_pho@Site of DNA damage

References
a_re1480( Apoptosis  map ):
PMID:18001824
PMID:18006705
a_re1481:( Apoptosis  map ) reactionType:is.a
a_re1501( Apoptosis  map ):
influenceDelete: re to products
PMID:18087291
review
a_re1503( Apoptosis  map ):
influenceDelete: re to reactants

MDC1|​T752_don|​T699_don|​T719_don|​Nter-SDT-motifs_pho@Site of DNA damage

References
a_re1481:( Apoptosis  map ) reactionType:is.a
a_re1478( Apoptosis  map ):
influenceDelete: re to products
PMID:18087291
review, more specifically retention of NBN
PMID:18001824
NBN interacts even with MDC1 mutated on its 3 phosphoacceptor sites

MDC1|​Nter-SDT-motifs_pho@Site of DNA damage

References
a_re1479( Apoptosis  map ):
PMID:16377563
PMID:16049003
a_re1480( Apoptosis  map ):
PMID:18001824
PMID:18006705
a_re1482:( Apoptosis  map ) reactionType:is.a

MDC1@Nucleus

References
a_re1483:( Apoptosis  map ) PMID:18411308

MDC1|​Nter-SDT-motifs_pho@Nucleus

References
a_re1483:( Apoptosis  map ) PMID:18411308
a_re1479( Apoptosis  map ):
PMID:16377563
PMID:16049003

MDC1@default

References
d_re148( DNA repair  map ):
PMID:18006705
PMID:18583988

MDC1|​pho@default

References
d_re148( DNA repair  map ):
PMID:18006705
PMID:18583988
d_re149:( DNA repair  map ) PMID:17303408, PMID:16377563


Modifications:
In compartment: Nucleus
  1. MDC1@Nucleus map

  2. MDC1|​Nter-SDT-motifs_pho@Nucleus map

In compartment: Site of DNA damage

  1. MDC1|​Nter-SDT-motifs_pho@Site of DNA damage map

  2. MDC1|​T752_don|​T699_don|​T719_don|​Nter-SDT-motifs_pho@Site of DNA damage map
  3. MDC1|​T752_pho|​T699_pho|​T719_pho|​Nter-SDT-motifs_pho@Site of DNA damage map

In compartment: default

  1. MDC1@default map

  2. MDC1|​pho@default map

Participates in complexes:
In compartment: default

  1. MDC1|​pho:​RNF8@default map

  2. H2AFX|​pho|​ubi:​MDC1|​pho@default map
  3. ATM|​pho|​S367_pho|​S1893_pho:​H2AFX|​pho|​ubi:​MDC1|​pho:​MRE11*:​NBS1*|​S343_pho:​RAD50@default map

Participates in reactions:
As Reactant or Product:

  1. MDC1|​Nter-SDT-motifs_pho@Nucleus map map MDC1|​Nter-SDT-motifs_pho@Site of DNA damage map

  2. MDC1|​Nter-SDT-motifs_pho@Site of DNA damage map map MDC1|​T752_pho|​T699_pho|​T719_pho|​Nter-SDT-motifs_pho@Site of DNA damage map
  3. MDC1|​T752_pho|​T699_pho|​T719_pho|​Nter-SDT-motifs_pho@Site of DNA damage map map MDC1|​T752_don|​T699_don|​T719_don|​Nter-SDT-motifs_pho@Site of DNA damage map
  4. MDC1|​Nter-SDT-motifs_pho@Site of DNA damage map map MDC1|​T752_don|​T699_don|​T719_don|​Nter-SDT-motifs_pho@Site of DNA damage map
  5. MDC1@Nucleus map map MDC1|​Nter-SDT-motifs_pho@Nucleus map
  6. MDC1@default map map MDC1|​pho@default map
  7. H2AFX|​pho|​ubi@default map + MDC1|​pho@default map map H2AFX|​pho|​ubi:​MDC1|​pho@default map
  8. RNF8@default map + MDC1|​pho@default map map MDC1|​pho:​RNF8@default map
  9. ATM|​pho|​S367_pho|​S1893_pho:​MRE11*:​NBS1*|​S343_pho:​RAD50@default map + H2AFX|​pho|​ubi:​MDC1|​pho@default map map ATM|​pho|​S367_pho|​S1893_pho:​H2AFX|​pho|​ubi:​MDC1|​pho:​MRE11*:​NBS1*|​S343_pho:​RAD50@default map

As Catalyser:

  1. NBS1*@Site of DNA damage map map NBS1*@Nucleus map

  2. TP53BP1@Site of DNA damage map map TP53BP1@Site of DNA damage map
  3. BRCA1@Site of DNA damage map map BRCA1@Site of DNA damage map
  4. RNF8@Nucleus map map RNF8@Site of DNA damage map
  5. gHR_DNA_st1*@Nucleus map map gHR_DNA_st2*@Nucleus map
  6. S phase@default map map G2 phase@default map
  7. G2 phase@default map map M phase@default map
  8. Ku80*@default map map Ku80*|​ubi@default map
  9. gHR_DNA_st2*@Nucleus map map gHR_DNA_st3*@Nucleus map
  10. H2AFX|​pho@default map map H2AFX|​pho|​ubi@default map
  11. ATM@default map map ATM|​pho|​S367_pho|​S1893_pho|​active@default map
  12. CHEK2@default map map CHEK2|​pho|​active@default map
  13. Ku70*@default map + Ku80*@default map map Ku70*:​Ku80*@Nucleus map
  14. DNA-PK*@default map map DNA-PK*|​pho@default map

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