Gene MCL1

Identifiers
myeloid cell leukemia sequence 1 (BCL2-related)
HUGO:MCL1 HGNC:6943 ENTREZ:4170 UNIPROT:Q07820 GENECARDS:MCL1 KEGG:4170 ATLASONC:GC_MCL1 WIKI:MCL1

Maps_Modules
 Apoptosis   / APOPTOSIS_GENES 
 Apoptosis   / MITOCH_METABOLISM 
 Apoptosis   / MOMP_REGULATION 
 Survival   / PI3K_AKT_MTOR 

References
PMID:20540941
PMID:10454566

gMCL1@Nucleus

References
a_re106( Apoptosis  ):
PMID:18208354
TP53 downregulates the activity of the MCL1 gene promoter in Hela and HEK293
mainly through an unkown mechanism. Critical importance of the -41 to +16 region that correspond to TATA-BP and other basal transcription factors binding
also through down regulation of Sp1
PMID:19808698
in MV4-11 cells, a human biphenotypic B myelomonocytic leukemia that displays FLT3-ITD mutation (constitutive FLT3 signalling), STAT5* siRNA prevents MCL1 expression
PMID:11160159
in large granular lymphocyte high STAT3 activity correlates with MCL1 expression, AG-490 JAK inhibitors induce apoptosis and decreases MCL1 expression.
in NIH3T3, upon v-src, STAT3 dependent expression of MCL1

gMCL1@Gene compartment

References
c_re958:( Cell cycle  ) PMID:11857079

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Modifications:
In compartment: Gene compartment

1. gMCL1@Gene compartment

In compartment: Nucleus

1. gMCL1@Nucleus

Participates in complexes:

Participates in reactions:
As Reactant or Product:

1. gMCL1@Nucleus → rMCL1@Nucleus

2. E2F1_alone@Cytoplasm → gMCL1@Gene compartment
3. gMCL1@Nucleus → rMCL1@Nucleus

As Catalyser: