Identifiers
myeloid cell leukemia sequence 1 (BCL2-related)
HUGO:MCL1 HGNC:6943 ENTREZ:4170 UNIPROT:Q07820 GENECARDS:MCL1 KEGG:4170 ATLASONC:GC_MCL1 WIKI:MCL1
Maps_Modules
Apoptosis / APOPTOSIS_GENES
Apoptosis / MITOCH_METABOLISM
Apoptosis / MOMP_REGULATION
Survival / PI3K_AKT_MTOR
References
PMID:20540941
PMID:10454566
gMCL1@Nucleus
References
a_re106( Apoptosis ):
PMID:18208354
TP53 downregulates the activity of the MCL1 gene promoter in Hela and HEK293
mainly through an unkown mechanism. Critical importance of the -41 to +16 region that correspond to TATA-BP and other basal transcription factors binding
also through down regulation of Sp1
PMID:19808698
in MV4-11 cells, a human biphenotypic B myelomonocytic leukemia that displays FLT3-ITD mutation (constitutive FLT3 signalling), STAT5* siRNA prevents MCL1 expression
PMID:11160159
in large granular lymphocyte high STAT3 activity correlates with MCL1 expression, AG-490 JAK inhibitors induce apoptosis and decreases MCL1 expression.
in NIH3T3, upon v-src, STAT3 dependent expression of MCL1
gMCL1@Gene compartment
References
c_re958:( Cell cycle ) PMID:11857079
Modifications:
In compartment: Gene compartment
In compartment: Nucleus
Participates in complexes:
Participates in reactions:
As Reactant or Product:
- gMCL1@Nucleus
→
rMCL1@Nucleus
- E2F1_alone@Cytoplasm
→
gMCL1@Gene compartment
- gMCL1@Nucleus
→
rMCL1@Nucleus
As Catalyser: