MCL1

RNA MCL1 map

Identifiers
myeloid cell leukemia sequence 1 (BCL2-related)
HUGO:MCL1 HGNC:6943 ENTREZ:4170 UNIPROT:Q07820 GENECARDS:MCL1 KEGG:4170 ATLASONC:GC_MCL1 WIKI:MCL1

Maps_Modules
 Apoptosis  map  / APOPTOSIS_GENES  map
 Apoptosis  map  / MITOCH_METABOLISM  map
 Apoptosis  map  / MOMP_REGULATION  map
 Survival  map  / PI3K_AKT_MTOR  map

References
PMID:20540941
PMID:10454566

rMCL1@Nucleus

References
a_re106( Apoptosis  map ):
PMID:18208354
TP53 downregulates the activity of the MCL1 gene promoter in Hela and HEK293
mainly through an unkown mechanism. Critical importance of the -41 to +16 region that correspond to TATA-BP and other basal transcription factors binding
also through down regulation of Sp1
PMID:19808698
in MV4-11 cells, a human biphenotypic B myelomonocytic leukemia that displays FLT3-ITD mutation (constitutive FLT3 signalling), STAT5* siRNA prevents MCL1 expression
PMID:11160159
in large granular lymphocyte high STAT3 activity correlates with MCL1 expression, AG-490 JAK inhibitors induce apoptosis and decreases MCL1 expression.
in NIH3T3, upon v-src, STAT3 dependent expression of MCL1
a_re44( Apoptosis  map ):
PMID:17404574
in human immortalized non malignant H69 cholangiocyte and malignant KMCH cholangiocarcinoma cell lines, MIR29B1 targets MCL1
PMID:19155302
MCL1 is a target of MIR101
PMID:19676043
in DBTRG-05MG human glioblastoma cell line, MCL1 targeted by MIR153
PMID:19654003
in H2009 human lung adenocarcinoma cells, MCL1 is a target of MIR133B
PMID:19966861
in Jurkat, HeLa, U937, glycolysis inhibition by 2deoxy glucose causes a specific block in transltion of MCL1, through a AMPK – TOR pathway


Modifications:
In compartment: Nucleus
  1. rMCL1@Nucleus map

Participates in complexes:

    Participates in reactions:
    As Reactant or Product:

    1. gMCL1@Nucleus map map rMCL1@Nucleus map

    2. rMCL1@Nucleus map map MCL1@Mitochondrial outer membrane map
    3. gMCL1@Nucleus map map rMCL1@Nucleus map

    As Catalyser:

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