MCL1

Protein MCL1 map

Identifiers
myeloid cell leukemia sequence 1 (BCL2-related)
HUGO:MCL1 HGNC:6943 ENTREZ:4170 UNIPROT:Q07820 GENECARDS:MCL1 KEGG:4170 ATLASONC:GC_MCL1 WIKI:MCL1

Maps_Modules
 Apoptosis  map  / APOPTOSIS_GENES  map
 Apoptosis  map  / MITOCH_METABOLISM  map
 Apoptosis  map  / MOMP_REGULATION  map

MCL1|​S159_unk@Mitochondrial outer membrane

References
a_re45:( Apoptosis  map ) reactionType:is.a
a_re42( Apoptosis  map ):
influenceDelete: reactants to re
we consider only that CASP3 or GZMB activity can influence Bax recruitment to membrane, not the fact that MCL1 increases it
hierarchical:post-MOMP
reactionType:proteases.cleavage
PMID:15713684
in different human cancer cell lines by Granzyme B
PMID:15637055
in Jurkat leukemia T cells, by CASP3 upon TRAIL-induced apoptosis
a_re586( Apoptosis  map ):
PMID:15486085
MCL1-BIM interaction in mitochondrial fraction independent of BIM S65 phosphorylation status
PMID:15724238
in human tonsil B cells, constitutive interaction
a_re605( Apoptosis  map ):
PMID:11546872
in HEK293T, coIP
Y2H
a_re612( Apoptosis  map ):
PMID:15031724
Y2H with human cDNA
a_re1417( Apoptosis  map ):
PMID:20501829
in DU-145 upon ER stress induced by IL24 ectopic expression

MCL1|​S159_pho|​ubi@Mitochondrial outer membrane

References
a_re41( Apoptosis  map ):
PMID:15989957
in Hela MCL1 ubiquitination mainly on lysines 136, 194, and 197
purification of MCL1 E3 ubiquitin ligase from the cytosol of Hela cells
in vitro reconstitution of the system
HUWE1 KD
PMID:16543145
suggest that HUWE1 preferentially target S159 phosphorylated MCL1 for polyubiquitination
PMID:16213503
HUWE1 is a BH3 domain protein – competition HUWE1 / Bim for binding to MCL1
a_re95( Apoptosis  map ):
PMID:20023629
in Hela and 293T, ectopically expressed USP9X binds and deubiquitinylates MCL1.
in human follicular lymphomas, USP9X overexpression correlates with MCL1 expression.

MCL1|​S159_pho@Mitochondrial outer membrane

References
a_re40( Apoptosis  map ):
logical:re40_s128_re45=FALSE
PMID:16543145
in different IL-3 dependent mouse pro-B cell lines upon IL-3 withdrawal
in Hela and 293T
S159 phosphorylation site correspond to human MCL1
GSK3A and GSK3B KD in NIH3T3
a_re95( Apoptosis  map ):
PMID:20023629
in Hela and 293T, ectopically expressed USP9X binds and deubiquitinylates MCL1.
in human follicular lymphomas, USP9X overexpression correlates with MCL1 expression.
a_re41( Apoptosis  map ):
PMID:15989957
in Hela MCL1 ubiquitination mainly on lysines 136, 194, and 197
purification of MCL1 E3 ubiquitin ligase from the cytosol of Hela cells
in vitro reconstitution of the system
HUWE1 KD
suggest that HUWE1 preferentially target S159 phosphorylated MCL1 for polyubiquitination
PMID:16213503
HUWE1 is a BH3 domain protein – competition HUWE1 / Bim for binding to MCL1
a_re45:( Apoptosis  map ) reactionType:is.a

MCL1@Mitochondrial outer membrane

References
a_re44( Apoptosis  map ):
PMID:17404574
in human immortalized non malignant H69 cholangiocyte and malignant KMCH cholangiocarcinoma cell lines, MIR29B1 targets MCL1
PMID:19155302
MCL1 is a target of MIR101
PMID:19676043
in DBTRG-05MG human glioblastoma cell line, MCL1 targeted by MIR153
PMID:19654003
in H2009 human lung adenocarcinoma cells, MCL1 is a target of MIR133B
PMID:19966861
in Jurkat, HeLa, U937, glycolysis inhibition by 2deoxy glucose causes a specific block in transltion of MCL1, through a AMPK – TOR pathway
a_re40( Apoptosis  map ):
logical:re40_s128_re45=FALSE
PMID:16543145
in different IL-3 dependent mouse pro-B cell lines upon IL-3 withdrawal
in Hela and 293T
S159 phosphorylation site correspond to human MCL1
GSK3A and GSK3B KD in NIH3T3
a_re46:( Apoptosis  map ) reactionType:is.a


Modifications:
In compartment: Mitochondrial outer membrane
  1. MCL1@Mitochondrial outer membrane map

  2. MCL1|​S159_pho@Mitochondrial outer membrane map
  3. MCL1|​S159_unk@Mitochondrial outer membrane map
  4. MCL1|​S159_pho|​ubi@Mitochondrial outer membrane map

Participates in complexes:
In compartment: Mitochondrial outer membrane

  1. BCL2L11:​MCL1@Mitochondrial outer membrane map

  2. HRK:​MCL1|​S159_unk@Mitochondrial outer membrane map
  3. BAK1:​MCL1|​S159_unk@Mitochondrial outer membrane map
  4. BBC3:​MCL1|​S159_unk@Mitochondrial outer membrane map
  5. MCL1|​S159_unk:​PMAIP1@Mitochondrial outer membrane map
  6. BMF|​unk:​MCL1|​S159_unk@Mitochondrial outer membrane map
  7. MCL1|​S159_unk:​cleaved_BID*|​myr@Mitochondrial outer membrane map

Participates in reactions:
As Reactant or Product:

  1. MCL1|​S159_unk@Mitochondrial outer membrane map + BAK1@Mitochondrial outer membrane map map BAK1:​MCL1|​S159_unk@Mitochondrial outer membrane map

  2. MCL1@Mitochondrial outer membrane map map MCL1|​S159_pho@Mitochondrial outer membrane map
  3. MCL1|​S159_pho@Mitochondrial outer membrane map map MCL1|​S159_pho|​ubi@Mitochondrial outer membrane map
  4. MCL1|​S159_unk@Mitochondrial outer membrane map map cleaved~MCL1*@Mitochondrial outer membrane map
  5. rMCL1@Nucleus map map MCL1@Mitochondrial outer membrane map
  6. MCL1|​S159_pho@Mitochondrial outer membrane map map MCL1|​S159_unk@Mitochondrial outer membrane map
  7. MCL1@Mitochondrial outer membrane map map MCL1|​S159_unk@Mitochondrial outer membrane map
  8. MCL1|​S159_pho|​ubi@Mitochondrial outer membrane map map degraded
  9. BCL2L11@Mitochondrial outer membrane map + MCL1|​S159_unk@Mitochondrial outer membrane map map BCL2L11:​MCL1@Mitochondrial outer membrane map
  10. cleaved_BID*|​myr@Mitochondrial outer membrane map + MCL1|​S159_unk@Mitochondrial outer membrane map map MCL1|​S159_unk:​cleaved_BID*|​myr@Mitochondrial outer membrane map
  11. BBC3@Mitochondrial outer membrane map + MCL1|​S159_unk@Mitochondrial outer membrane map map BBC3:​MCL1|​S159_unk@Mitochondrial outer membrane map
  12. PMAIP1@Mitochondrial outer membrane map + MCL1|​S159_unk@Mitochondrial outer membrane map map MCL1|​S159_unk:​PMAIP1@Mitochondrial outer membrane map
  13. BMF|​unk@Mitochondrial outer membrane map + MCL1|​S159_unk@Mitochondrial outer membrane map map BMF|​unk:​MCL1|​S159_unk@Mitochondrial outer membrane map
  14. HRK@Mitochondrial outer membrane map + MCL1|​S159_unk@Mitochondrial outer membrane map map HRK:​MCL1|​S159_unk@Mitochondrial outer membrane map
  15. MCL1|​S159_pho|​ubi@Mitochondrial outer membrane map map MCL1|​S159_pho@Mitochondrial outer membrane map

As Catalyser:

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