e_re828( EMT ):
GEF activity of MCF2 (DBL) towards CDC42 or Rac1 is enhanced upon TNK2 (ACK1) phosphorylation.
e_re891( EMT ):
GEFs are essential for CDC42 activation. They promote the exchange of GDP to GTP to generate the activated form of CDC42 capable of recognizing downstram targets.
MCF2 (DBL) as a GEF of CDC42
In compartment: Cytoplasm
Participates in complexes:
Participates in reactions:
As Reactant or Product:
- Rac1_GEFs*@Cytoplasm → MCF2|pho|active@Cytoplasm
- MCF2@Cytoplasm → MCF2|pho|active@Cytoplasm
- CDC42_GEFs*@Cytoplasm → MCF2|pho|active@Cytoplasm