MBD4:MLH1

Complex MBD4:MLH1 map


Complex composition:

  1. MLH1 map
  2. MBD4 map




MBD4:​MLH1@default

Identifiers
NAME:MBD4:MLH1

Maps_Modules
 DNA repair  map  / BER  map
 DNA repair  map  / MMR  map

References
BER and MMR interaction and G2/M arrest in response to o6-meG formation
PMID:14614141
d_re5( DNA repair  map ):
9-1-1 complex activates TDG glycosylase and activates BER:
PMID:17855402
DNA with O6-methylguanine adducts, MutSalpha and MutLalpha activate ATR/ATRIP and BER pathways performs the repair:
PMID:16713580, PMID:18543256
d_re26( DNA repair  map ):
BER and MMR interaction and G2/M arrest in responce to o6-meG formation:
cMyc physically stimulates MSH2 and MLH1 and activates MMR:
PMID:15814658, PMID:12584560
d_re120( DNA repair  map ):
By CycB*/CDC2*:
G2/M transition
PMID:16818604
For BRCA2 and FANCD2/FANCDI importance in the cytokinesis and localisation at the spindle and role in the propagation of mitosis:
PMID:15375219, PMID:19686080
CDC2 has to be phosphorylated fot inhibition of G2 to M propagation (called G2 checkpoint). FANCC activates CDC2 phosphorylation
PMID:15377654
Brca1 ubiquitinates CtIp and in complex they inhibit G2 to M propagation (G2 checkpoint)
PMID:16818604, PMID:15485915
BRCA1 and FANCJ in complex inhibit G2 to M propagation (called G2 checkpoint).
PMID:15242590
FANCM:FAAP24 complex activated G2 phase checpoint (G2 to M propagation inhibition):
PMID:18995830
ATR kinase activation mediated by MutSalpha and MutLalpha in response to cytotoxic O6-methylguanine adducts. O6-methylguanine adducts recognized by MutSalpha, MutLalpha and BER pathways performs the repair:

Confidence
REF=5 FUNC=5


Modifications:
Participates in complexes:
In compartment: default
  1. MBD4:​MLH1@default map

Participates in reactions:
As Reactant or Product:

  1. MLH1@default map + MBD4@default map map MBD4:​MLH1@default map

As Catalyser:

  1. G2 phase@default map map M phase@default map

  2. gMismatched_nucleotide*@Nucleus map map gMMR_DNA_st2*@Nucleus map
  3. gDeaminated_alkylated_mismatched_base*@Nucleus map map gBER_M-glyc_DNA_st2*@Nucleus map + Base@default map

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