MAX

Protein MAX map

Identifiers
MYC associated factor X
HUGO:MAX HGNC:6913 ENTREZ:4149 UNIPROT:P61244 GENECARDS:MAX REACTOME:404599 KEGG:4149 ATLASONC:GC_MAX WIKI:MAX
“MAX protein”

Maps_Modules
 Apoptosis  map  / APOPTOSIS_GENES  map
 DNA repair  map  / G1_S_CHECKPOINT  map
 Cell cycle  map  / E2F6  map
 Survival  map  / MAPK  map

References
PMID:2006410, PMID:15121849, PMID:8425218, PMID:16908182
MAX interacts with the transcription factor C-MYC enabling C-MYC to trans-activate at least a subset of its target genes. MAX is phosphorylated by P38 through complex formation (not represented here).
PMID:11274345

MAX@Nucleus

References
a_re706( Apoptosis  map ):
PMID:11031250
review
a_re1174:( Apoptosis  map ) PMID:8425219

MAX@Cytoplasm

References
s_mpk1_re166( Survival  map ):
MAX is phosphorylated by P38 through complex formation (not represented here).
PMID:11274345

MAX|​pho@Cytoplasm

References
s_mpk1_re166( Survival  map ):
MAX is phosphorylated by P38 through complex formation (not represented here).
PMID:11274345
s_mpk1_re279( Survival  map ):
MAX interacts with the transcription factor C-MYC enabling C-MYC to trans-activate at least a subset of its target genes.
GSK3 is constitutively active in unstimulated cells and phosphorylates many proteins (including glycogen synthase C-MYC and cyclin D) to keep them in inactive states or promote their degradation.
PMID:11274345 PMID:12040186


Modifications:
In compartment: Cytoplasm
  1. MAX@Cytoplasm map

  2. MAX|​pho@Cytoplasm map

In compartment: Nucleus

  1. MAX@Nucleus map

In compartment: default

  1. MAX@default map

Participates in complexes:
In compartment: Nucleus

  1. MAX:​MXD1@Nucleus map

  2. MAX:​MXI1@Nucleus map

In compartment: default

  1. MAX:​MYC@default map

Participates in reactions:
As Reactant or Product:

  1. MAX@Nucleus map + MXI1@Nucleus map map MAX:​MXI1@Nucleus map

  2. MAX@Nucleus map + MYC@Nucleus map map a_s3297
  3. MAX@Nucleus map + MXD1@Nucleus map map MAX:​MXD1@Nucleus map
  4. MAX@default map + MYC@default map map MAX:​MYC@default map
  5. MAX@Cytoplasm map map MAX|​pho@Cytoplasm map

As Catalyser:

  1. gMismatched_nucleotide*@Nucleus map map gMMR_DNA_st2*@Nucleus map

  2. gCyclinD*@default map map rCyclinD*@default map
  3. gCDC25A@default map map rCDC25A@default map
  4. MYC@Nucleus map map Proliferation@Cytoplasm map

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