MAP3K5

Protein MAP3K5 map

Identifiers
mitogen-activated protein kinase kinase kinase 5
MEKK5
HUGO:MAP3K5 HGNC:6857 ENTREZ:4217 UNIPROT:Q99683 GENECARDS:MAP3K5 KEGG:4217 ATLASONC:GC_MAP3K5 WIKI:MAP3K5

Maps_Modules
 EMT  map  / EMT_REGULATORS  map
 Survival  map  / MAPK  map

References
PMID:11274345
PMID:12655147
ASK1 is a MAP3K and can activate both JNK and P38 pathways.
TNF-dependent production of ROS triggers the dissociation of Trx from ASK1 and the consequently liberalised ASK1 binds to TRAF2. Finally TRAF2 appears to activate ASK1 (by phosphorylation) by enhancing and stabilising the oligomerisation of ASK1.
PMID:12556535
IGF1R signaling suppresses the ASK1-mediated stimulation of JNK/p38 thus supresses the induction of apoptosis.
PMID:11274345 PMID:12655147

MAP3K5@Cytoplasm

References
e_re1621( EMT  map ):
PMID:11274345
PMID:12655147
ASK1 is a MAP3K and can activate both JNK and P38 pathways.
TNF-dependent production of ROS triggers the dissociation of Trx from ASK1 and the consequently liberalised ASK1 binds to TRAF2. Finally TRAF2 appears to activate ASK1 (by phosphorylation) by enhancing and stabilising the oligomerisation of ASK1.
PMID:12556535
IGF1R signaling suppresses the ASK1-mediated stimulation of JNK/p38 thus supresses the induction of apoptosis.

MAP3K5|​pho@Cytoplasm

References
e_re1621( EMT  map ):
PMID:11274345
PMID:12655147
ASK1 is a MAP3K and can activate both JNK and P38 pathways.
TNF-dependent production of ROS triggers the dissociation of Trx from ASK1 and the consequently liberalised ASK1 binds to TRAF2. Finally TRAF2 appears to activate ASK1 (by phosphorylation) by enhancing and stabilising the oligomerisation of ASK1.
PMID:12556535
IGF1R signaling suppresses the ASK1-mediated stimulation of JNK/p38 thus supresses the induction of apoptosis.


Modifications:
In compartment: Cytoplasm
  1. MAP3K5@Cytoplasm map

  2. MAP3K5|​pho@Cytoplasm map

Participates in complexes:
In compartment: Cytoplasm

  1. MAP3K5|​pho:​TNFRSF1B@Cytoplasm map

Participates in reactions:
As Reactant or Product:

  1. MAP3K5@Cytoplasm map map MAP3K5|​pho@Cytoplasm map

  2. MAP3K5@Cytoplasm map map Apoptosis@Cytoplasm map
  3. s_s_mpk1_s1037 map MAP3K5@Cytoplasm map + TXN@Cytoplasm map
  4. RIPK1:​TNFRSF1A:​TRADD:​TRAF2@Plasma Membrane map + MAP3K5@Cytoplasm map map s_s_mpk1_s1048
  5. TNFRSF1B:​TRAF2@Plasma Membrane map + MAP3K5@Cytoplasm map map MAP3K5|​pho:​TNFRSF1B@Cytoplasm map

As Catalyser:

  1. MAP2K4@Cytoplasm map map MAP2K4|​pho|​pho@Cytoplasm map

  2. MAP2K3@Cytoplasm map map MAP2K3|​pho|​pho@Cytoplasm map
  3. MAP2K7@Cytoplasm map map MAP2K7|​pho|​pho@Cytoplasm map
  4. MAP2K6@Cytoplasm map map MAP2K6|​pho|​pho@Cytoplasm map

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