MAP3K4

Protein MAP3K4 map

Identifiers
mitogen-activated protein kinase kinase kinase 4
MEKK4
HUGO:MAP3K4 HGNC:6856 ENTREZ:4216 UNIPROT:Q9Y6R4 GENECARDS:MAP3K4 KEGG:4216 ATLASONC:GC_MAP3K4 WIKI:MAP3K4

Maps_Modules
 Survival  map  / MAPK  map

References
MEKK4 is a MAP3K and can activate both JNK and P38 pathways. It may be an effector for stress pathways activated by genotoxins.
PMID:11274345

MAP3K4@Cytoplasm

References
s_mpk1_re143( Survival  map ):
Expression of GADD45 genes in mammalian cells strongly activates co-expressed MTK1 as well as P38 and JNK the MAPKs downstream of MTK1.
GADD45alpha/beta are direct MEKK4 interactors. They are involved in genotoxin regulation of MEKK4 signalling to JNK and P38
PMID:21614932 PMID:11274345


Modifications:
In compartment: Cytoplasm
  1. MAP3K4@Cytoplasm map

Participates in complexes:
In compartment: Cytoplasm

  1. GADD45*:​MAP3K4|​pho@Cytoplasm map

Participates in reactions:
As Reactant or Product:

  1. GADD45*@Cytoplasm map + MAP3K4@Cytoplasm map map GADD45*:​MAP3K4|​pho@Cytoplasm map

As Catalyser:

  1. MAP2K4@Cytoplasm map map MAP2K4|​pho|​pho@Cytoplasm map

  2. MAP2K3@Cytoplasm map map MAP2K3|​pho|​pho@Cytoplasm map
  3. MAP2K6@Cytoplasm map map MAP2K6|​pho|​pho@Cytoplasm map

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