s_mpk1_re140:( Survival ) Activation of MEKK2 and MEKK3 is assumed to follow the same mechanisms of MEKK1 activation
s_mpk1_re153( Survival ):
MLK3 and MLK2 two MAP3Ks of JNK pathway can interact with RAC1 in a GTP-dependent manner.
MEKK2 and MEKK3 can activate JNK P38 and ERK pathways.
TAO kinases are novel MAP3Ks that specifically regulate P38s.
ASK1 is a MAP3K and can activate both JNK and P38 pathways.
MEKK1 selectively activates the endogenous JNK pathway. MEKK1 can activate MEK4 and MEK7 in vivo.
MEKK4 is a MAP3K and can activate both JNK and P38 pathways.
TAK1 is a MAP3K. It is able to activate both JNK and P38 pathways.
Endogenous TAK1 is activated by TGF-beta IL-1 and TNF. TAK1 can phosphorylate and activate MEK4 MEK3 and MEK6.
MLK3 has the potential to positively regulate the ERK / MAPK pathway by directly phosphorylating and activating MEK.
Expression of GADD45 genes in mammalian cells strongly activates co-expressed MTK1 as well as P38 and JNK the MAPKs downstream of MTK1. TAO kinases are MAP3Ks that function upstream of P38 and JNK.
PMID:11274345 PMID:12738796 PMID:18855897 PMID:21614932
s_mpk1_re186( Survival ):
s_s_mpk1_re186( Survival ):
Participates in complexes:
In compartment: Cytoplasm
Participates in reactions:
As Reactant or Product:
- GRB2:RAS*|pho:RTK*:SOS*@Plasma Membrane + MAP3K2_3*@Cytoplasm → MAP3K2_3*|pho:RAS*|pho:RTK*@Cytoplasm