MAP3K1:TNFRSF1B

Complex MAP3K1:TNFRSF1B map


Complex composition:

  1. MAP3K1 map
  2. TNFRSF1B map




MAP3K1|​pho:​TNFRSF1B@Cytoplasm

Identifiers
NAME:MAP3K1:TNFRSF1B

References
s_mpk1_re139( Survival  map ):
MEKK1 is significantly activated by TNF. Oligomerisation of TRAFs is sufficient to trigger MEKK1 binding. MEKK1 associates selectively with oligomerised TRAF2 in vivo in a TNF-dependent manner.
PMID:11274345
s_mpk1_re157( Survival  map ):
MLK3 and MLK2 two MAP3Ks of JNK pathway can interact with RAC1 in a GTP-dependent manner.
MEKK2 and MEKK3 can activate JNK P38 and ERK pathways.
TAO kinases are novel MAP3Ks that specifically regulate P38s.
ASK1 is a MAP3K and can activate both JNK and P38 pathways.
MEKK1 selectively activates the endogenous JNK pathway. MEKK1 can activate MEK4 and MEK7 in vivo.
MEKK4 is a MAP3K and can activate both JNK and P38 pathways.
TAK1 is a MAP3K. It is able to activate both JNK and P38 pathways.
Endogenous TAK1 is activated by TGF-beta IL-1 and TNF. TAK1 can phosphorylate and activate MEK4 MEK3 and MEK6.
MLK3 has the potential to positively regulate the ERK / MAPK  map pathway by directly phosphorylating and activating MEK.
Expression of GADD45 genes in mammalian cells strongly activates co-expressed MTK1 as well as P38 and JNK the MAPKs downstream of MTK1. TAO kinases are MAP3Ks that function upstream of P38 and JNK.
PMID:11274345 PMID:12738796 PMID:18855897 PMID:21614932

Confidence
REF=1 FUNC=5


Modifications:
Participates in complexes:
In compartment: Cytoplasm
  1. MAP3K1|​pho:​TNFRSF1B@Cytoplasm map

Participates in reactions:
As Reactant or Product:

  1. MAP3K1@Cytoplasm map + TNFRSF1B:​TRAF2@Plasma Membrane map map MAP3K1|​pho:​TNFRSF1B@Cytoplasm map

As Catalyser:

  1. MAP2K7@Cytoplasm map map MAP2K7|​pho|​pho@Cytoplasm map

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