MAP3K7_10_11*

Protein MAP3K7_10_11* map

Identifiers
MAP3K10_11*
mitogen-activated protein kinase kinase kinase 11
MLK3, PTK1
HUGO:MAP3K11 HGNC:6850 ENTREZ:4296 UNIPROT:Q16584 GENECARDS:MAP3K11 KEGG:4296 ATLASONC:GC_MAP3K11 WIKI:MAP3K11
mitogen-activated protein kinase kinase kinase 10
MLK2
HUGO:MAP3K10 HGNC:6849 ENTREZ:4294 UNIPROT:Q02779 GENECARDS:MAP3K10 KEGG:4294 ATLASONC:GC_MAP3K10 WIKI:MAP3K10
mitogen-activated protein kinase kinase kinase 7
TAK1
HUGO:MAP3K7 HGNC:6859 ENTREZ:6885 UNIPROT:O43318 GENECARDS:MAP3K7 REACTOME:168070 KEGG:6885 ATLASONC:MAP3K7ID454ch6q15 WIKI:MAP3K7

Maps_Modules
 EMT  map  / EMT_REGULATORS  map
 EMT  map  / CYTOSKELETON_POLARITY  map

MAP3K7_10_11*@Cytoplasm

References
e_re765( EMT  map ):
Rac1 activates JNK pathway vai PAK-independent mechanisms involving binding and stimulation of MAP3K (MAP3K10 and MAP3K11)
PMID:8910292
MLK3 overexpression is sufficient to activate JNK po- tently without affecting the phosphorylating activity of MAPK or p38
MLK3 binds the GTP-binding proteins Cdc42 and Rac1 in vivo and that MLK3 mediates activation of MEKK-SEK-JNK kinase cascade by Rac1 and Cdc42
PMID:9427749
MLK2 (MAP3K10) and MLK3 (MAP3K11) interact with the activated (GTP-bound) forms of Rac and Cdc42, with a slight preference for Rac.
When expressed in fibroblasts, MLK2 co-localizes with active, dually phosphorylated JNK to punctate structures along microtubules.
MLK2 and MLK3 interact with members of the KIF3 family of kinesin superfamily motor proteins and with KAP3A, the putative targeting component of KIF3 motor complex
PMID:11713255
Rac1 coordinately activates p70S6K and JNK via MLK3 activation


Modifications:
In compartment: Cytoplasm
  1. MAP3K7_10_11*@Cytoplasm map

Participates in complexes:

    Participates in reactions:
    As Reactant or Product:

    1. MAP3K7_10_11*@Cytoplasm map map MAP3K7@Cytoplasm map

    2. MAP3K7_10_11*@Cytoplasm map map MAP3K10@Cytoplasm map
    3. MAP3K7_10_11*@Cytoplasm map map MAP3K11@Cytoplasm map
    4. MAP3K7_10_11*@Cytoplasm map map MAP3K7_10_11*@Cytoplasm map
    5. MAP3K7_10_11*@Cytoplasm map map JNK pathway@Cytoplasm map

    As Catalyser:

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