MAP3K1

Protein MAP3K1 map

Identifiers
mitogen-activated protein kinase kinase kinase 1 E3 ubiquitin protein ligase
MEKK1 “mitogen-activated protein kinase kinase kinase 1″
HUGO:MAP3K1 HGNC:6848 ENTREZ:4214 UNIPROT:Q13233 GENECARDS:MAP3K1 REACTOME:58885 KEGG:4214 ATLASONC:GC_MAP3K1 WIKI:MAP3K1

Maps_Modules
 Survival  map  / MAPK  map

References
MEKK1 (MAP3K1) is a key MAP3K.
MEKK1 is significantly activated by TNF. Oligomerisation of TRAFs is sufficient to trigger MEKK1 binding. MEKK1 associates selectively with oligomerised TRAF2 in vivo in a TNF-dependent manner. MEKK1 can interact with Ras in a GTP-dependent manner. The GTP-dependent coupling of MEKK1 to Ras indicates that MEKK1 may be an effector for those agonists that recruit JNK through Ras-dependent mechanisms. MEKK1 selectively activates the endogenous JNK pathway. MEKK1 can activate MEK4 and MEK7 in vivo.
PMID:18855897 PMID:11274345

MAP3K1@Cytoplasm

References
s_mpk1_re137( Survival  map ):
MEKK1 can interact with Ras in a GTP-dependent manner. The GTP-dependent coupling of MEKK1 to Ras indicates that MEKK1 may be an effector for those agonists that recruit JNK through Ras-dependent mechanisms.
PMID:11274345
s_mpk1_re138( Survival  map ):
MEKK1 is significantly activated by TNF. Oligomerisation of TRAFs is sufficient to trigger MEKK1 binding. MEKK1 associates selectively with oligomerised TRAF2 in vivo in a TNF-dependent manner.
s_s_mpk1_re138( Survival  map ):


Modifications:
In compartment: Cytoplasm
  1. MAP3K1@Cytoplasm map

Participates in complexes:
In compartment: Cytoplasm

  1. MAP3K1|​pho:​TNFRSF1B@Cytoplasm map

  2. MAP3K1|​pho:​RAS*|​pho:​RTK*@Cytoplasm map

Participates in reactions:
As Reactant or Product:

  1. GRB2:​RAS*|​pho:​RTK*:​SOS*@Plasma Membrane map + MAP3K1@Cytoplasm map map MAP3K1|​pho:​RAS*|​pho:​RTK*@Cytoplasm map

  2. MAP3K1@Cytoplasm map + RIPK1:​TNFRSF1A:​TRADD:​TRAF2@Plasma Membrane map map s_s_mpk1_s1046
  3. MAP3K1@Cytoplasm map + TNFRSF1B:​TRAF2@Plasma Membrane map map MAP3K1|​pho:​TNFRSF1B@Cytoplasm map

As Catalyser:

  1. MAP2K4@Cytoplasm map map MAP2K4|​pho|​pho@Cytoplasm map

  2. MAP2K7@Cytoplasm map map MAP2K7|​pho|​pho@Cytoplasm map

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