MAP2K4

Protein MAP2K4 map

Identifiers
mitogen-activated protein kinase kinase 4
HUGO:MAP2K4 HGNC:6844 ENTREZ:6416 UNIPROT:P45985 GENECARDS:MAP2K4 REACTOME:59509 KEGG:6416 ATLASONC:MAP2K4ID244ch17p12 WIKI:MAP2K4
SERK1

Maps_Modules
 Apoptosis  map  / TNF_RESPONSE  map
 Survival  map  / MAPK  map

References
synonym:MKK4 synonym:MEK4
MAP2K for JNK pathway. MEK4 is weakly activated by TNF and IL-1.
PMID:11274345

MAP2K4|​pho@Cytoplasm

References
a_re1315( Apoptosis  map ):
PMID:12624093
in mouse embryonic cells, with targeted disruption of either MAP2K4 or MAP2K7, the phosphorylation pattern of JNK reveals sequential phosphorylation by these MAP2Ks

MAP2K4|​pho|​pho@Cytoplasm

References
s_mpk1_re153( Survival  map ):
MLK3 and MLK2 two MAP3Ks of JNK pathway can interact with RAC1 in a GTP-dependent manner.
MEKK2 and MEKK3 can activate JNK P38 and ERK pathways.
TAO kinases are novel MAP3Ks that specifically regulate P38s.
ASK1 is a MAP3K and can activate both JNK and P38 pathways.
MEKK1 selectively activates the endogenous JNK pathway. MEKK1 can activate MEK4 and MEK7 in vivo.
MEKK4 is a MAP3K and can activate both JNK and P38 pathways.
TAK1 is a MAP3K. It is able to activate both JNK and P38 pathways.
Endogenous TAK1 is activated by TGF-beta IL-1 and TNF. TAK1 can phosphorylate and activate MEK4 MEK3 and MEK6.
MLK3 has the potential to positively regulate the ERK / MAPK  map pathway by directly phosphorylating and activating MEK.
Expression of GADD45 genes in mammalian cells strongly activates co-expressed MTK1 as well as P38 and JNK the MAPKs downstream of MTK1. TAO kinases are MAP3Ks that function upstream of P38 and JNK.
PMID:11274345 PMID:12738796 PMID:18855897 PMID:21614932
s_mpk1_re156( Survival  map ):
MEK4 and MEK7 can activate all JNK isoforms (by phosphorylation).
PMID:11274345


Modifications:
In compartment: Cytoplasm
  1. MAP2K4@Cytoplasm map

  2. MAP2K4|​pho@Cytoplasm map
  3. MAP2K4|​pho|​pho@Cytoplasm map

Participates in complexes:

    Participates in reactions:
    As Reactant or Product:

    1. MAP2K4@Cytoplasm map map MAP2K4|​pho@Cytoplasm map

    2. MAP2K4@Cytoplasm map map MAP2K4|​pho|​pho@Cytoplasm map

    As Catalyser:

    1. JNK*@Cytoplasm map map JNK*|​Y185_pho@Cytoplasm map

    2. p38*@Cytoplasm map map p38*|​T180_pho|​Y182_pho@Cytoplasm map
    3. JNK*@Cytoplasm map map JNK*|​pho|​pho@Cytoplasm map

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