MAP2K3

Protein MAP2K3 map

Identifiers
mitogen-activated protein kinase kinase 3
HUGO:MAP2K3 HGNC:6843 ENTREZ:5606 UNIPROT:P46734 GENECARDS:MAP2K3 REACTOME:167935 KEGG:5606 ATLASONC:GC_MAP2K3 WIKI:MAP2K3
PRKMK3

Maps_Modules
 Apoptosis  map  / TNF_RESPONSE  map
 Survival  map  / MAPK  map

References
synonym:MKK3 synonym:MEK3
MAP2K for P38 pathway. MEK3 is more strongly activated by physical and chemical stresses than by other stimuli.
PMID:11274345

MAP2K3|​pho|​pho@Cytoplasm

References
s_mpk1_re154( Survival  map ):
MLK3 and MLK2 two MAP3Ks of JNK pathway can interact with RAC1 in a GTP-dependent manner.
MEKK2 and MEKK3 can activate JNK P38 and ERK pathways.
TAO kinases are novel MAP3Ks that specifically regulate P38s.
ASK1 is a MAP3K and can activate both JNK and P38 pathways.
MEKK1 selectively activates the endogenous JNK pathway. MEKK1 can activate MEK4 and MEK7 in vivo.
MEKK4 is a MAP3K and can activate both JNK and P38 pathways.
TAK1 is a MAP3K. It is able to activate both JNK and P38 pathways.
Endogenous TAK1 is activated by TGF-beta IL-1 and TNF. TAK1 can phosphorylate and activate MEK4 MEK3 and MEK6.
MLK3 has the potential to positively regulate the ERK / MAPK  map pathway by directly phosphorylating and activating MEK.
Expression of GADD45 genes in mammalian cells strongly activates co-expressed MTK1 as well as P38 and JNK the MAPKs downstream of MTK1. TAO kinases are MAP3Ks that function upstream of P38 and JNK.
PMID:11274345 PMID:12738796 PMID:18855897 PMID:21614932
s_mpk1_re155( Survival  map ):
MEK3 and MEK6 are high selective for P38 activation (by phosphorylation).
PMID:11274345


Modifications:
In compartment: Cytoplasm
  1. MAP2K3@Cytoplasm map

  2. MAP2K3|​pho@Cytoplasm map
  3. MAP2K3|​pho|​pho@Cytoplasm map

Participates in complexes:

    Participates in reactions:
    As Reactant or Product:

    1. MAP2K3@Cytoplasm map map MAP2K3|​pho@Cytoplasm map

    2. MAP2K3@Cytoplasm map map MAP2K3|​pho|​pho@Cytoplasm map

    As Catalyser:

    1. p38*@Cytoplasm map map p38*|​T180_pho|​Y182_pho@Cytoplasm map

    2. p38*@Cytoplasm map map p38*|​pho|​pho@Cytoplasm map

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