M phase

Phenotype M phase map
M phase@default

d_re120( DNA repair  map ):
By CycB*/CDC2*:
G2/M transition
For BRCA2 and FANCD2/FANCDI importance in the cytokinesis and localisation at the spindle and role in the propagation of mitosis:
PMID:15375219, PMID:19686080
CDC2 has to be phosphorylated fot inhibition of G2 to M propagation (called G2 checkpoint). FANCC activates CDC2 phosphorylation
Brca1 ubiquitinates CtIp and in complex they inhibit G2 to M propagation (G2 checkpoint)
PMID:16818604, PMID:15485915
BRCA1 and FANCJ in complex inhibit G2 to M propagation (called G2 checkpoint).
FANCM:FAAP24 complex activated G2 phase checpoint (G2 to M propagation inhibition):
ATR kinase activation mediated by MutSalpha and MutLalpha in response to cytotoxic O6-methylguanine adducts. O6-methylguanine adducts recognized by MutSalpha, MutLalpha and BER pathways performs the repair:
PMID:16713580, PMID:18543256
BER and MMR interaction and G2/M arrest inresponce to o6-meG formation:
d_re195( DNA repair  map ):
FANCM is phosphorylated by PLK1 and beta-TRCP in response to G2/M checkpoint. Phosphorylated FANCM is degraded and FANCONI pathway is inhibited during mitosis.
d_re216( DNA repair  map ):
By CDC20/APC complex:
M to G1 transition
By Mitotic checkpoint complex:
Spindle checkpoint
PARP3 activated spindle checkpoint
Tankyrase activated spindle checkpoint

In compartment: default
  1. M phase@default map

Participates in complexes:

    Participates in reactions:
    As Reactant or Product:

    1. G2 phase@default map map M phase@default map

    2. M phase@default map map G1 phase@default map

    As Catalyser:

    1. FANCM|​pho@default map map degraded

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