LTBP1

Protein LTBP1 map

Identifiers
latent transforming growth factor beta binding protein 1
HUGO:LTBP1 HGNC:6714 ENTREZ:4052 UNIPROT:Q14766 GENECARDS:LTBP1 REACTOME:58745 ATLASONC:GC_LTBP1 WIKI:LTBP1

Maps_Modules
 EMT  map  / ECM  map

References
PMID:21900405
LTBPs are microfibril-associated proteins that tether latent TGFB to the ECM
There are 4 LTBP proteins (1, 2, 3, 4). Although LTBP1 and 3 bind all three TGFB (1, 2, 3), LTBP4 binds only TGFB1
PMID:9931372
LTBP1 is a member of the fibrillin family
An extracellular fibrillar structure containing LTBP1 was found in both the basement membrane of epithelia and mesenchymal tissue in which extensive tissue remodeling is carried out
PMID:10544215
Extracellular tTgase is located at the basal and apical surfaces of cells and at cell–cell contacts, and that LTBP1 is co-distributed with cell surface tTgase
LTPB1 was also found to co-localize with both intracellular and extracellular fibronectin
Regulation of tTgase expression is important for controlling matrix storage of latent TGFB1 complexes
Fibronectin may be one extracellular component to which LTBP1 is crosslinked when LTBP1 and tTgase interact at the cell surface


Modifications:
In compartment: Extracellular space
  1. LTBP1@Extracellular space map

Participates in complexes:
In compartment: Extracellular space

  1. LTBP1:​Latency-associated protein*|​hm2@Extracellular space map

  2. Integrin A8B1_AVB1_AVB5_AVB6_AVB8*:​LTBP1:​Latency-associated protein*|​hm2@Extracellular space map
  3. LTBP1:​Latency-associated protein*|​hm2:​TGFB1|​hm2@Extracellular space map
  4. Integrin A8B1_AVB1_AVB5_AVB6_AVB8*:​LTBP1:​Latency-associated protein*|​hm2:​TGFB1|​hm2@Extracellular space map
  5. Actin cytoskeletal*:​Integrin A8B1_AVB1_AVB5_AVB6_AVB8*:​LTBP1:​Latency-associated protein*|​hm2:​TGFB1|​hm2@Extracellular space map

Participates in reactions:
As Reactant or Product:

  1. Latency-associated protein*|​hm2:​TGFB1|​hm2@Extracellular space map + LTBP1@Extracellular space map map LTBP1:​Latency-associated protein*|​hm2:​TGFB1|​hm2@Extracellular space map

  2. Integrin A8B1_AVB1_AVB5_AVB6_AVB8*@Extracellular space map + LTBP1:​Latency-associated protein*|​hm2:​TGFB1|​hm2@Extracellular space map map Integrin A8B1_AVB1_AVB5_AVB6_AVB8*:​LTBP1:​Latency-associated protein*|​hm2:​TGFB1|​hm2@Extracellular space map
  3. Actin cytoskeletal*@Cytoplasm map + Integrin A8B1_AVB1_AVB5_AVB6_AVB8*:​LTBP1:​Latency-associated protein*|​hm2:​TGFB1|​hm2@Extracellular space map map Actin cytoskeletal*:​Integrin A8B1_AVB1_AVB5_AVB6_AVB8*:​LTBP1:​Latency-associated protein*|​hm2:​TGFB1|​hm2@Extracellular space map
  4. LTBP1:​Latency-associated protein*|​hm2:​TGFB1|​hm2@Extracellular space map map TGFB1|​hm2|​active@Extracellular space map + LTBP1:​Latency-associated protein*|​hm2@Extracellular space map
  5. Actin cytoskeletal*:​Integrin A8B1_AVB1_AVB5_AVB6_AVB8*:​LTBP1:​Latency-associated protein*|​hm2:​TGFB1|​hm2@Extracellular space map map Integrin A8B1_AVB1_AVB5_AVB6_AVB8*:​LTBP1:​Latency-associated protein*|​hm2@Extracellular space map + TGFB1|​hm2|​active@Extracellular space map

As Catalyser:

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