LRRK2

Protein LRRK2 map

Identifiers
leucine-rich repeat kinase 2
HUGO:LRRK2 HGNC:18618 ENTREZ:120892 UNIPROT:Q5S007 GENECARDS:LRRK2 KEGG:120892 ATLASONC:GC_LRRK2 WIKI:LRRK2

Maps_Modules
 Survival  map  / WNT_NON_CANONICAL  map

LRRK2@Cytoplasm

References
s_wnc2_re47( Survival  map ):
LRKK2 mediates binding of NFAT to NRON and other components, but this is independent of its kinase activity and independent of the phosphorylation status of NFAT
PMID:21983832
s_wnc2_re48:( Survival  map ) PMID:21709260


Modifications:
In compartment: Cytoplasm
  1. LRRK2@Cytoplasm map

Participates in complexes:
In compartment: Cytoplasm

  1. CSE1L:​Calmodulin*:​KPNB1:​LRRK2:​NFAT*:​NRON:​PPP3R*:​TNPO1:​Tubulin-_alpha_*@Cytoplasm map

  2. CSE1L:​KPNB1:​LRRK2:​NFAT*:​NRON:​PPP3CB_sub_trunc_endsub_*:​PPP3R*:​TNPO1:​Tubulin-_alpha_*@Cytoplasm map

Participates in reactions:
As Reactant or Product:

  1. Calmodulin*:​KPNB1:​NFAT*:​PPP3R*:​TNPO1:​Tubulin-_alpha_*@Cytoplasm map + LRRK2@Cytoplasm map + rNRON@Cytoplasm map + CSE1L@Cytoplasm map map CSE1L:​Calmodulin*:​KPNB1:​LRRK2:​NFAT*:​NRON:​PPP3R*:​TNPO1:​Tubulin-_alpha_*@Cytoplasm map

  2. KPNB1:​NFAT*:​PPP3CB_sub_trunc_endsub_*:​PPP3R*:​TNPO1:​Tubulin-_alpha_*@Cytoplasm map + LRRK2@Cytoplasm map + CSE1L@Cytoplasm map + rNRON@Cytoplasm map map CSE1L:​KPNB1:​LRRK2:​NFAT*:​NRON:​PPP3CB_sub_trunc_endsub_*:​PPP3R*:​TNPO1:​Tubulin-_alpha_*@Cytoplasm map

As Catalyser:

  1. Calmodulin*:​KPNB1:​NFAT*:​PPP3R*:​TNPO1:​Tubulin-_alpha_*@Cytoplasm map + LRRK2@Cytoplasm map + rNRON@Cytoplasm map + CSE1L@Cytoplasm map map CSE1L:​Calmodulin*:​KPNB1:​LRRK2:​NFAT*:​NRON:​PPP3R*:​TNPO1:​Tubulin-_alpha_*@Cytoplasm map

  2. KPNB1:​NFAT*:​PPP3CB_sub_trunc_endsub_*:​PPP3R*:​TNPO1:​Tubulin-_alpha_*@Cytoplasm map + LRRK2@Cytoplasm map + CSE1L@Cytoplasm map + rNRON@Cytoplasm map map CSE1L:​KPNB1:​LRRK2:​NFAT*:​NRON:​PPP3CB_sub_trunc_endsub_*:​PPP3R*:​TNPO1:​Tubulin-_alpha_*@Cytoplasm map

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