LMO2:ZEB1

Complex LMO2:ZEB1 map


Complex composition:

  1. LMO2 map
  2. ZEB1 map




LMO2:​ZEB1@Nucleus

Identifiers
NAME:LMO2:ZEB1

Maps_Modules
 EMT  map  / EMT_REGULATORS  map

References
e_re22( EMT  map ):
PMID:10048576
The gene expressions of MMP-1, MMP-3, and MMP-9 and gelatinolytic activity of MMP-9 were significantly increased in high ETS-1 expression cells.
Low ETS-1 expression cells could not spread on a vitronectin substratum, and the phosphorylation of focal adhesion kinase was markedly impaired because of the reduced expression of integrin b3
PMID:19208835
TCF8 (ZEB1) regulates cell invasion and migration via MMP1 expression.
TCF8 is likely to be dispensable for endothelial cell motility.
One possible mechanism underlying the increased invasiveness and migration might be the up-regulated digestion of ECMs via TCF8-mediated transcriptional regulation of the gene encoding MMP1.
MMP1 induction during tube formation was significantly enhanced in Matrigel when TCF8 was silenced
PMID:21081489
MiR-200b Regulates Ets-1-associated Genes
Suppression of endogenous miR-200b induced MMP-1 and VEGFR2 expressions
Overexpression of Ets-1 did not completely reverse miR- 200b-associated MMP-1 and VEGFR2 down-regulation.
It indicates that miR-200b, apart from targeting Ets-1, might silence other target proteins involved in transcription of the indicated genes.
e_re24( EMT  map ):
PMID:13130303
Keratin-14, 18, 19, Vimentin are putative direct HIF1 target genes
http://www.omicsonline.org/1948-5956/JCST-03-035.php
Genes induced by HIF-1 in cancer cells include KRT-14, 18, 19, Vimentin, VEGF
PMID:9278421
HIF1 target genes include TGFB3, VEGF
PMID:7768934
VEGF is induced by hypoxia in a HIF1-dependent way
PMID:11528470
Prokinecticin 1 (EG-VEGF) is induced by hypoxia through a potential HIF1-dependent mechanism indicates that this gene is in the same homeostatic cascade as VEGF, Flt1 and erythropoietinPMID:17987801 PMID:16716598

Confidence
REF=5 FUNC=4


Modifications:
Participates in complexes:
In compartment: Nucleus
  1. LMO2:​ZEB1@Nucleus map

Participates in reactions:
As Reactant or Product:

  1. ZEB1@Nucleus map + LMO2@Nucleus map map LMO2:​ZEB1@Nucleus map

As Catalyser:

  1. gMMP1@Nucleus map map rMMP1@Nucleus map

  2. gVEGFA@Nucleus map map rVEGFA@Nucleus map

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