LIMK2

Protein LIMK2 map

Identifiers
LIM domain kinase 2
HUGO:LIMK2 HGNC:6614 ENTREZ:3985 UNIPROT:P53671 GENECARDS:LIMK2 REACTOME:58573 ATLASONC:GC_LIMK2 WIKI:LIMK2

Maps_Modules
 EMT  map  / EMT_REGULATORS  map
 EMT  map  / CYTOSKELETON_POLARITY  map

LIMK2@Cytoplasm

References
e_re847( EMT  map ):
CDC42 promotes changes in actin cytoskeleton by several pathways.
PMID:10461188
PMID:11950587
PMID:11340065
PMID:10559936
PMID:10613909
PMID:11413130
CDC42 activates PAK1,2,3,4 and CDC42BPA (MRCKalpha) which phosphorylate LIMK1,2.
LIMK1,2 subsquently phosphorylate and inhibit Cofilin
Destrin as actin depolymerizing factor, once phosphorylated by LIMK1,2 is inactive and thus this phosphorylation leads to actin polymerization and stimulation of filopodia and stress fibers formation.

LIMK2|​pho|​active@Cytoplasm

References
e_re847( EMT  map ):
CDC42 promotes changes in actin cytoskeleton by several pathways.
PMID:10461188
PMID:11950587
PMID:11340065
PMID:10559936
PMID:10613909
PMID:11413130
CDC42 activates PAK1,2,3,4 and CDC42BPA (MRCKalpha) which phosphorylate LIMK1,2.
LIMK1,2 subsquently phosphorylate and inhibit Cofilin
Destrin as actin depolymerizing factor, once phosphorylated by LIMK1,2 is inactive and thus this phosphorylation leads to actin polymerization and stimulation of filopodia and stress fibers formation.


Modifications:
In compartment: Cytoplasm
  1. LIMK2@Cytoplasm map

  2. LIMK2|​pho|​active@Cytoplasm map

Participates in complexes:

    Participates in reactions:
    As Reactant or Product:

    1. LIMK2@Cytoplasm map map LIMK2|​pho|​active@Cytoplasm map

    2. LIMK1_2*@Cytoplasm map map LIMK2|​pho|​active@Cytoplasm map

    As Catalyser:

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