LIMK1_2*

Protein LIMK1_2* map

Identifiers
LIMK1_2*
LIM domain kinase 1
HUGO:LIMK1 HGNC:6613 ENTREZ:3984 UNIPROT:P53667 GENECARDS:LIMK1 REACTOME:58571 KEGG:3984 ATLASONC:LIMK1ID41159ch7q11 WIKI:LIMK1
LIM domain kinase 2
HUGO:LIMK2 HGNC:6614 ENTREZ:3985 UNIPROT:P53671 GENECARDS:LIMK2 REACTOME:58573 ATLASONC:GC_LIMK2 WIKI:LIMK2

Maps_Modules
 EMT  map  / EMT_REGULATORS  map
 EMT  map  / CYTOSKELETON_POLARITY  map

LIMK1_2*@Cytoplasm

References
e_re471( EMT  map ):
PMID:22154077, PMID:17522712
CDC42 promotes changes in actin cytoskeleton by several pathways.
PMID:10461188
PMID:11950587
PMID:11340065
PMID:10559936
PMID:10613909
PMID:11413130
CDC42 activates PAK1,2,3,4 and CDC42BPA (MRCKalpha) which phosphorylate LIMK1,2.
LIMK1,2 subsquently phosphorylate and inhibit Cofilin
Destrin as actin depolymerizing factor, once phosphorylated by LIMK1,2 is inactive and thus this phosphorylation leads to actin polymerization and stimulation of filopodia and stress fibers formation.
PMID:15866889
The ARP2_3 complex and Cofilin are involved in protrusion at the leading edge: the actin-severing activity of cofilin and the actin-branching activity of Arp2_3 act in synergy to drive the extension of lamellipodia.
Cofilin is also required for the maintenance of a polarized cytoskeleton and thus for directional cell migration.
Integrins control motile strategy through a Rho-cofilin pathway.
Adhesion to fibronectin by a5b1 integrin leads to phosphorylation and thus inactivation of cofilin.
Cells thus fail to polarize their cytoskeleton but extend thin protrusion with cell-matrix adhesions in multiple directions.


Modifications:
In compartment: Cytoplasm
  1. LIMK1_2*@Cytoplasm map

Participates in complexes:

    Participates in reactions:
    As Reactant or Product:

    1. LIMK1_2*@Cytoplasm map map LIMK1|​pho|​active@Nucleus map

    2. LIMK1_2*@Cytoplasm map map LIMK2|​pho|​active@Cytoplasm map

    As Catalyser:

    1. CFL1@Cytoplasm map map CFL1|​pho@Cytoplasm map

    2. DSTN@Cytoplasm map map DSTN|​pho@Cytoplasm map

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