LIMK1

Protein LIMK1 map

Identifiers
LIM domain kinase 1
HUGO:LIMK1 HGNC:6613 ENTREZ:3984 UNIPROT:P53667 GENECARDS:LIMK1 REACTOME:58571 KEGG:3984 ATLASONC:LIMK1ID41159ch7q11 WIKI:LIMK1

Maps_Modules
 EMT  map  / EMT_REGULATORS  map
 EMT  map  / CYTOSKELETON_POLARITY  map

LIMK1@Cytoplasm

References
e_re472( EMT  map ):
PMID:22154077, PMID:17522712
CDC42 promotes changes in actin cytoskeleton by several pathways.
PMID:10461188
PMID:11950587
PMID:11340065
PMID:10559936
PMID:10613909
PMID:11413130
CDC42 activates PAK1,2,3,4 and CDC42BPA (MRCKalpha) which phosphorylate LIMK1,2.
LIMK1,2 subsquently phosphorylate and inhibit Cofilin
Destrin as actin depolymerizing factor, once phosphorylated by LIMK1,2 is inactive and thus this phosphorylation leads to actin polymerization and stimulation of filopodia and stress fibers formation.
PMID:11018042
LIMK1 is regulated by Pak1,

LIMK1|​pho|​active@Nucleus

References
e_re472( EMT  map ):
PMID:22154077, PMID:17522712
CDC42 promotes changes in actin cytoskeleton by several pathways.
PMID:10461188
PMID:11950587
PMID:11340065
PMID:10559936
PMID:10613909
PMID:11413130
CDC42 activates PAK1,2,3,4 and CDC42BPA (MRCKalpha) which phosphorylate LIMK1,2.
LIMK1,2 subsquently phosphorylate and inhibit Cofilin
Destrin as actin depolymerizing factor, once phosphorylated by LIMK1,2 is inactive and thus this phosphorylation leads to actin polymerization and stimulation of filopodia and stress fibers formation.
PMID:11018042
LIMK1 is regulated by Pak1,


Modifications:
In compartment: Cytoplasm
  1. LIMK1@Cytoplasm map

In compartment: Nucleus

  1. LIMK1|​pho|​active@Nucleus map

Participates in complexes:

    Participates in reactions:
    As Reactant or Product:

    1. LIMK1@Cytoplasm map map LIMK1|​pho|​active@Nucleus map

    2. LIMK1_2*@Cytoplasm map map LIMK1|​pho|​active@Nucleus map

    As Catalyser:

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