LEF1_TCF3_4*

Protein LEF1_TCF3_4* map

Identifiers
LEF/TCF3*
transcription factor 4
HUGO:TCF4 HGNC:11634 ENTREZ:6925 UNIPROT:P15884 GENECARDS:TCF4 REACTOME:57613 KEGG:6925 ATLASONC:GC_TCF4 WIKI:TCF4
lymphoid enhancer-binding factor 1
HUGO:LEF1 HGNC:6551 ENTREZ:51176 UNIPROT:Q9UJU2 GENECARDS:LEF1 KEGG:51176 ATLASONC:GC_LEF1 WIKI:LEF1
transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47)
HUGO:TCF3 HGNC:11633 ENTREZ:6929 UNIPROT:P15923 GENECARDS:TCF3 REACTOME:65901 KEGG:6929 ATLASONC:E2A WIKI:TCF3

Maps_Modules
 EMT  map  / EMT_REGULATORS  map
 EMT  map  / CELL_CELL_ADHESIONS  map
 EMT  map  / ADHERENS_JUNCTIONS  map

LEF1_TCF3_4*@Nucleus

References
e_re527( EMT  map ):
PMID:19751508
PMID:22270359
PMID:16940750
-In the absence of Wnt ligands, b-catenin is phosphorylated by CK1 and GSK-3 in the context of a destruction complex with APC and Axin.
Phosphorylated b-catenin is consequently targeted for ubiquitination and degraded.
-In the presence of Wnt lignads, upon ligand binding, DVL1 (dishevelled) recruits the Axin-GSK-3 complex, resulting in the sequential phosphorylation of LRP6 by CK1 and GSK-3.
Phoshorylated LRP6 serves as a docking site for additional Axin-GSK-3 complex, resulting in the disassembly of the destruction complex.
Non phosphorylated and thus stabilized b-catenin translocates to the nucleus where it activates transcription of target genes together with LEF/TCFs
PMID:19020303
When Wnt binds its receptor, Frizzled, beta-catenin is released to translocate from the cytoplasm to the nucleus, where it forms a complex with TCF and/or LEF transcription factors and stimulates cyclin D1 gene transcription
(Beta-catenin/TCF)- mediated cyclin D1 gene transcription is further regulated by active Rac signaling, phosphorylation by protein kinase A (PKA)
PMID:15377999
Rac1-GTP augments nuclear accumulation of b-catenin and physical association of Rac1 with b-catenin and/or TCF-4 may facilitate this process.
This culminates in the amplification of b-catenin signaling activity, resulting in enhanced transcriptional activation of perhaps a specific subset of Wnt target genes important in cancer progression.
e_re620( EMT  map ):
PMID:17143293
The size of the LEF/TCF family is small: approximately 4 members in vertebrates.
The LEF/TCF family exhibits extensive patterns of alternative splicing, alternative promoter usage and activities of both repression and activation.
All LEF/TCFs bind b-catenin.
PMID:17143294


Modifications:
In compartment: Nucleus
  1. LEF1_TCF3_4*@Nucleus map

Participates in complexes:
In compartment: Nucleus

  1. LEF1_TCF3_4*:​_beta_-Catenin*@Nucleus map

Participates in reactions:
As Reactant or Product:

  1. LEF1_TCF3_4*@Nucleus map map TCF3@Nucleus map

  2. LEF1_TCF3_4*@Nucleus map + _beta_-Catenin*@Cytoplasm map map LEF1_TCF3_4*:​_beta_-Catenin*@Nucleus map
  3. LEF1_TCF3_4*@Nucleus map map LEF1@Nucleus map
  4. LEF1_TCF3_4*@Nucleus map map TCF4@Nucleus map

As Catalyser:

  1. gMYC@Nucleus map map rMYC@Nucleus map

  2. gID2@Nucleus map map rID2@Nucleus map
  3. gAXIN2@Nucleus map map rAXIN2@Nucleus map
  4. gSNAI2@Nucleus map map rSNAI2@Nucleus map
  5. gCyclinD1*@Nucleus map map rCyclinD1*@Nucleus map
  6. gClaudin1*@Nucleus map map rClaudin1*@Nucleus map
  7. gClaudin2*@Nucleus map map rClaudin2*@Nucleus map
  8. gFibronectin*@Nucleus map map rFibronectin*@Nucleus map

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