Latency-associated protein*

Protein Latency-associated protein* map

Identifiers
latency-associated protein*
HUGO:TGFB1 HGNC:11766 ENTREZ:7040 UNIPROT:P01137 GENECARDS:TGFB1 REACTOME:65937 KEGG:7040 ATLASONC:GC_TGFB1 WIKI:TGFB1
HUGO:TGFB3 HGNC:11769 ENTREZ:7043 UNIPROT:P10600 GENECARDS:TGFB3 REACTOME:65943 KEGG:7043 ATLASONC:GC_TGFB3 WIKI:TGFB3
HUGO:TGFB2 HGNC:11768 ENTREZ:7042 UNIPROT:P61812 GENECARDS:TGFB2 REACTOME:65939 KEGG:7042 ATLASONC:GC_TGFB2 WIKI:TGFB2

Maps_Modules
 EMT  map  / EMT_REGULATORS  map
 EMT  map  / ECM  map

References
PMID:21900405
LAP: Latency-associated peptiden encoded by TGFB gene
There are 3 LAPs (1, 2, 3) corresponding to 3 TGFB (1, 2, 3)
LAP1 contains the RGD motif which is the binding site for integrins aVb1, aVb3, aVb5, aVb6, aVb8, a8b1
PMID:19920116
LAP is known to bind to ITG heterodimers and activate TGFB.
LAP and TGFB were also prominently expressed at the basal surface of endometrial epitheliaModules_bigin:

Latency-associated protein*|​hm2@Extracellular space

References
e_re226( EMT  map ):
PMID:20519943
PMID:17934056
PMID:16474430
PMID:14557817
PMID:21900405
TGFB inhibits proliferation
TGFB overproduction causes fibrosis.
Each TGFB gene encodes a preproprotein sequence consisting of a signal peptide, a propeptide (LAP) and the mature TGFB
After translocation into the endoplamic reticulum, TGFB proprotein monomers form homomdimers liked by disulfide bonds, forming pro-TGFB
In the Golgi, the prodomains undergo glycosylation.
Also in the Golgi, FURIN hydolyzes the leavage site from LAP, creating TGFB and LAP-derived homodimers
The 2 homodimers remain noncovalently associated and are secreted.
The LAP-derived homodimer prevents TGFB from binding TGFB receptors.


Modifications:
In compartment: Extracellular space
  1. Latency-associated protein*|​hm2@Extracellular space map

Participates in complexes:
In compartment: Extracellular space

  1. Latency-associated protein*:​TGFB1@Extracellular space map

  2. LTBP1:​Latency-associated protein*|​hm2@Extracellular space map
  3. Latency-associated protein*|​hm2:​TGFB1|​hm2@Extracellular space map
  4. Latency-associated protein*|​hm2:​TGFB1|​hm2@Extracellular space map
  5. Integrin A8B1_AVB1_AVB5_AVB6_AVB8*:​LTBP1:​Latency-associated protein*|​hm2@Extracellular space map
  6. LTBP1:​Latency-associated protein*|​hm2:​TGFB1|​hm2@Extracellular space map
  7. Integrin A8B1_AVB1_AVB5_AVB6_AVB8*:​LTBP1:​Latency-associated protein*|​hm2:​TGFB1|​hm2@Extracellular space map
  8. Actin cytoskeletal*:​Integrin A8B1_AVB1_AVB5_AVB6_AVB8*:​LTBP1:​Latency-associated protein*|​hm2:​TGFB1|​hm2@Extracellular space map

Participates in reactions:
As Reactant or Product:

  1. Latency-associated protein*|​hm2@Extracellular space map + TGFB1|​hm2|​active@Extracellular space map map Latency-associated protein*|​hm2:​TGFB1|​hm2@Extracellular space map

  2. Latency-associated protein*|​hm2:​TGFB1|​hm2@Extracellular space map + LTBP1@Extracellular space map map LTBP1:​Latency-associated protein*|​hm2:​TGFB1|​hm2@Extracellular space map
  3. Integrin A8B1_AVB1_AVB5_AVB6_AVB8*@Extracellular space map + LTBP1:​Latency-associated protein*|​hm2:​TGFB1|​hm2@Extracellular space map map Integrin A8B1_AVB1_AVB5_AVB6_AVB8*:​LTBP1:​Latency-associated protein*|​hm2:​TGFB1|​hm2@Extracellular space map
  4. Actin cytoskeletal*@Cytoplasm map + Integrin A8B1_AVB1_AVB5_AVB6_AVB8*:​LTBP1:​Latency-associated protein*|​hm2:​TGFB1|​hm2@Extracellular space map map Actin cytoskeletal*:​Integrin A8B1_AVB1_AVB5_AVB6_AVB8*:​LTBP1:​Latency-associated protein*|​hm2:​TGFB1|​hm2@Extracellular space map
  5. Latency-associated protein*|​hm2:​TGFB1|​hm2@Extracellular space map map Latency-associated protein*|​hm2@Extracellular space map + TGFB1|​hm2|​active@Extracellular space map
  6. LTBP1:​Latency-associated protein*|​hm2:​TGFB1|​hm2@Extracellular space map map TGFB1|​hm2|​active@Extracellular space map + LTBP1:​Latency-associated protein*|​hm2@Extracellular space map
  7. Latency-associated protein*:​TGFB1@Extracellular space map map Latency-associated protein*|​hm2:​TGFB1|​hm2@Extracellular space map
  8. Actin cytoskeletal*:​Integrin A8B1_AVB1_AVB5_AVB6_AVB8*:​LTBP1:​Latency-associated protein*|​hm2:​TGFB1|​hm2@Extracellular space map map Integrin A8B1_AVB1_AVB5_AVB6_AVB8*:​LTBP1:​Latency-associated protein*|​hm2@Extracellular space map + TGFB1|​hm2|​active@Extracellular space map

As Catalyser:

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