Complex LAMTOR2:MEK*:MP1*

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Complex composition:

1. MEK*
2. LAMTOR2
3. MP1*

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LAMTOR2:​MEK*:​MP1*@Late Endosomes

Identifiers
NAME:LAMTOR2:MEK*:MP1*

References
s_mpk1_re18( Survival  ):
Formation of P14/MP1/MEK1 complex is required to activate the ERK cascade (and other processes) on late endosomes.
PMID:17178906
s_mpk1_re19( Survival  ):
Transfer of activated RTK/Grb2/Sos/RasGTP complex to late endosomes where it binds P14/MP1/MEK1 complex allowing the ERK cascade.
Upon EGF stimulation EGFR in complex with Grb2 is endocytosed and transported to late endosomes with Grb2-binding proteins such as Sos resulting in the activation of KRas on late endosomes.
PMID:17496910 PMID:19289794

Confidence
REF=2 FUNC=5

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Modifications:
Participates in complexes:
In compartment: Late Endosomes

1. LAMTOR2:​MEK*:​MP1*@Late Endosomes

Participates in reactions:
As Reactant or Product:

1. MEK*@Cytoplasm + LAMTOR2:​MP1*@Late Endosomes → LAMTOR2:​MEK*:​MP1*@Late Endosomes

2. GRB2:​RAS*|​pho:​RTK*:​SOS*@Plasma Membrane + LAMTOR2:​MEK*:​MP1*@Late Endosomes → GRB2:​LAMTOR2:​MEK*:​MP1*:​RAS*|​pho:​RTK*:​SOS*@Late Endosomes

As Catalyser: