Ku80*

Protein Ku80* map

Identifiers
X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)
HUGO:XRCC5 HGNC:12833 ENTREZ:7520 UNIPROT:P13010 GENECARDS:XRCC5 REACTOME:58275 KEGG:7520 ATLASONC:XRCC5ID337ch2q35 WIKI:XRCC5

Maps_Modules
 DNA repair  map  / C_NHEJ  map

References
PMID:20691907, PMID:19772495, PMID:19346677, PMID:15703371,
PMID:19847258, PMID:16697054, PMID:19473888, PMID:19808869,
PMID:19772495, PMID:24050180
Ku competes with PARP1 at the DNA binding site and inhibits alt_NHEJ
PMID:17088286

Ku80*|​ubi@default

References
d_re129( DNA repair  map ):
PMID:18809224
Complex RNF8:MDC1 ubiquitinates Ku80 and causes it’s dissociation from DNA and degradation.This bring to shift from C_NHEJ to HR:
PMID:18001825, PMID:18678709

Ku80*@default

References
d_re85:( DNA repair  map ) PMID:9242410


Modifications:
In compartment: default
  1. Ku80*@default map

  2. Ku80*|​ubi@default map

Participates in complexes:
In compartment: Nucleus

  1. Ku70*:​Ku80*@Nucleus map

  2. DNA-PK*:​Ku70*:​Ku80*:​WRN@Nucleus map
  3. Artemis*|​S645_pho|​S385_pho|​S516_pho|​S518_pho:​DNA-PK*|​hm2:​Ku70*:​Ku80*:​PARP3@Nucleus map
  4. APLF:​Artemis*|​S645_pho|​S385_pho|​S516_pho|​S518_pho:​DNA-PK*|​hm2:​Ku70*:​Ku80*:​LIG4:​PARP3:​XLF*:​XRCC4|​hm2@Nucleus map

In compartment: default

  1. Ku70*:​Ku80*:​Securin*@default map

Participates in reactions:
As Reactant or Product:

  1. Ku80*@default map map Ku80*|​ubi@default map

  2. Ku80*|​ubi@default map map degraded
  3. Ku70*:​Ku80*@Nucleus map + Securin*@default map map Ku70*:​Ku80*:​Securin*@default map
  4. Ku80*@default map + Ku70*@default map + WRN@Nucleus map + DNA-PK*@default map map DNA-PK*:​Ku70*:​Ku80*:​WRN@Nucleus map
  5. Ku70*@default map + Ku80*@default map map Ku70*:​Ku80*@Nucleus map
  6. Artemis*|​S645_pho|​S385_pho|​S516_pho|​S518_pho|​active@default map + LIG4:​XLF*:​XRCC4|​hm2@default map + PARP3@Nucleus map + DNA-PK*|​hm2|​active@default map + Ku80*@default map + Ku70*@Nucleus map + APLF@Nucleus map map APLF:​Artemis*|​S645_pho|​S385_pho|​S516_pho|​S518_pho:​DNA-PK*|​hm2:​Ku70*:​Ku80*:​LIG4:​PARP3:​XLF*:​XRCC4|​hm2@Nucleus map
  7. DNA-PK*|​hm2|​active@default map + Artemis*|​S645_pho|​S385_pho|​S516_pho|​S518_pho|​active@default map + Ku70*:​Ku80*@Nucleus map + PARP3@Nucleus map map Artemis*|​S645_pho|​S385_pho|​S516_pho|​S518_pho:​DNA-PK*|​hm2:​Ku70*:​Ku80*:​PARP3@Nucleus map

As Catalyser:

  1. gA_NHEJ_DNA_st1*@Nucleus map map gA_NHEJ_DNA_st2*@Nucleus map

  2. gC_NHEJ_DNA_st1*@Nucleus map map gC_NHEJ_DNA_st2*@Nucleus map
  3. gC_NHEJ_DNA_st3*@Nucleus map map gC_NHEJ_DNA_st4*@Nucleus map
  4. gC_NHEJ_DNA_st4*@Nucleus map map gC_NHEJ_DNA_st5*@Nucleus map

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