Ku70*:Ku80*

Complex Ku70*:Ku80* map


Complex composition:

  1. Ku80* map
  2. Ku70* map




Ku70*:​Ku80*@Nucleus

Identifiers
NAME:Ku70*:Ku80*

Maps_Modules
 DNA repair  map  / C_NHEJ  map

References
The complex presents in double amount to cover both ends of broken DNA double helix
Ku competes with PARP1 at the DNA binding site and inhibits alt_NHEJ
PMID:17088286
d_re79:( DNA repair  map ) PMID:19772495
d_re80( DNA repair  map ):
The complex MRN:BRCA1:phos-Ub-CtIP is central in the shift toward HR, because it activates resection for HR and blocks Ku70/80 of C_NHEJ:
PMID:19357644, PMID:15485915, PMID:19490890, PMID:18716619 (for CDK-dep phosph), PMID:20051983
d_re95:( DNA repair  map ) PMID:11955432, PMID:19772495
d_re105( DNA repair  map ):
PMID:18584027, PMID:17965729, PMID:20064462, PMID:18809224
For inhibition of A_NHEJ by DNA-PKs:
PMID:15211575
For stimulation of A_NHEJ by PARP1:
PMID:15498778, PMID:19362533, PMID:24050180
For role of MRN complex in A_NHEJ:
PMID:19654615, PMID:19892829
BLM inhibits A_NHEJ (alt_NHEJ):
PMID:24089143
PMID:24095737
d_re374( DNA repair  map ):
PMID:17962814
Link between spindle checkpoint and ds break DNA repair pathway (C_NHEJ)

Confidence
REF=5 FUNC=5


Modifications:
Participates in complexes:
In compartment: Nucleus
  1. Ku70*:​Ku80*@Nucleus map

Participates in reactions:
As Reactant or Product:

  1. Ku70*:​Ku80*@Nucleus map + Securin*@default map map Ku70*:​Ku80*:​Securin*@default map

  2. Ku70*@default map + Ku80*@default map map Ku70*:​Ku80*@Nucleus map
  3. DNA-PK*|​hm2|​active@default map + Artemis*|​S645_pho|​S385_pho|​S516_pho|​S518_pho|​active@default map + Ku70*:​Ku80*@Nucleus map + PARP3@Nucleus map map Artemis*|​S645_pho|​S385_pho|​S516_pho|​S518_pho:​DNA-PK*|​hm2:​Ku70*:​Ku80*:​PARP3@Nucleus map

As Catalyser:

  1. gA_NHEJ_DNA_st1*@Nucleus map map gA_NHEJ_DNA_st2*@Nucleus map

  2. gC_NHEJ_DNA_st1*@Nucleus map map gC_NHEJ_DNA_st2*@Nucleus map

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